EVALUATION OF ANTI-CANCER POTENTIAL OF PROTEINACIOUS EUPHORBIA TIRUCALLI AND OPUNTIAFICUS-INDICACACTUS EXTRACTS : IN VITRO STUDY

Fatma A Helal, Mohamed Galal, Aly Fahmy Mohamed

Abstract


Proteinacious materials of Euphorbia tirucalli and Opuntia ficus-indica have been utilized widely in society of medicine. This treatise aimed to evaluate the anti-cancer impact of cactus derived extracts on lung squamous cell carcinoma (A549) and colon cell carcinoma (Caco2). Data recorded revealed that a noteworthy inhibitory impact on cells proliferation went with some morphological changes that was cell type and concentration dependent. Likewise, up regulation of both casp-3 and Bax gene went with down regulation of Bcl-2 was identified 24 hrs post cell treatment. Information recorded uncovered that treatment with Euphorbia tirucalli and Opuntia ficus-indica extracts demonstrated clear anticancer potential accompanied with significantly elevated arrested cells during G2-M phase in both cell lines and significant apoptotic cell % induced under the effect of Opuntiaficus-indicaextract (P<0.05) than in case of Euphorbia extract treatment


Keywords


Cactus,Euphrbiatirucalli, opuntia, lung cancer, colon cancer, anti-cancer , cell cycle , apoptosis.

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References


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