CLINICAL PROFILE OF PATIENTS WITH TUBERCULOUS MENINGITIS: AN OBSERVATIONAL STUDY

Dr. Tejas Deshpande, Dr. Owez Virani

Abstract


Introduction: The study aims to highlight the different clinical features of tuberculous meningitis encountered at a tertiary centre in India. Not all cases of tuberculous meningitis present with the classical features of the disease and create a diagnostic dilemma. The study tries to assess these various manifestations of TB Meningitis.

Aim: To study the various presentations of patients with tuberculous meningitis in a tertiary care centre.

Methodology: Prospective observational study was carried out in a tertiary care centre with a final sample size of 71 patients. The clinical features of each of the 71 cases were noted and tabulated.

Results: 49 out of 71 patients presented with typical clinical features of Tuberculous Meningitis. Whereas, remaining 22 out of the 71 cases did not have the classical features.

Conclusion: The study highlights that Tuberculous Meningitis manifests as a plethora of symptoms not always forming a spectrum of disease.


Keywords


Meningitis, Tuberculosis, Tuberculoma, Clinical Features of TB Meningitis

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References


Chin H: Tuberculous meningitis: Diagnostic and therapeutic challenges. Neurol Clin Pract 4: 199 205, 2014.

Bartzatt R: Tuberculosis infections of the central nervous system. Cent Nerv Syst Agents Med Chem 11: 321 327, 2011.

World Health Organization: Global Tuberculosis Report 2013. http://www.who.int/tb/publications/global_report/en/index.html. Accessed January 10, 2014.

Christense AS, Andersen AB, Thomsen VO, Andersen PH and Johansen JS: Tuberculous meningitis in Denmark: A review of 50 cases. BMC Infect Dis 11: 47, 2011.

Yuchong C, Fubin C, Jianghan C, Fenglian W, Nan X, Minghui Y, Yalin S and Zhizhong Z: Cryptoccosis in China (1985 2010): Review of cases from Chinese population. Mycopathologia 173: 329 335, 2012.

Qu J, Zhou T, Zhong C, Deng R and Lü X: Comparison of clinical features and prognostic factors in HIV negative adults with cryp¬tococcal meningitis and tuberculous meningitis: A retrospective study. BMC Infect Dis 17: 51, 2017.

World Health Organization: Treatment of tuberculosis guide¬lines. 4th edition. http://whqlibdoc.who.int/publications/2010/9789241547833_eng.pdf.

Prasad K and Singh MB: Corticosteroids for managing tubercu¬lous meningitis. Cochrane Database Syst Rev: CD002244, 2008.

Tandon PN, Bhatia R, Bhargava S.Tuberculous Meningitis. In: Harris AA, editor. Handbook of clinical neurology [revised series]. Amsterdam: Elsevier Science; 1988.p.195-226.

Ramamurthi B, Varadarajan MG. Diagnosis of tuberculomas of brain. Clinical and radiological correlation. J Neurosurg 1961;18:1-7.

Kent SJ, Crowe SM, Yung A, Lucas CR, Mijch AM. Tuberculous meningitis: A 30 year review. Clin Infect Dis 1993;17:987-94.

Thomas MD, Chopra JS, Walia BN. Tuberculous meningitis. A clinical study of 232 cases. J Assoc Physicians India 1977;25:633-9.

Sheller JR, Des Prez RM. CNS Tuberculosis. Neurol Clin 1986;4:143-58.

Kocen RS, Parsons M. Neurological Complications of Tuberculosis: Some unusual manifestations. QJM 1970;39:17-30.

Berenguer J, Moreno S, Laguna F, Vicente T, Adrados M, Ortega A, et al. Tuberculous meningitis in patients infected with the human immunodeficiency virus. N Engl J Med 1992; 326:668-72.

Traub B, Colchester AE, Kingsley DP, Swash M. Tuberculosis of the central nervous system. QJM 1984;3:81-100.

Medical Research Council. Streptomycin treatment of tuberculous meningitis: Report of committee on streptomycin in tuberculosis trials. Lancet 1948;1:582-97.

Kennedy DH, Fallon RJ. Tuberculous meningitis. JAMA 1979;241:264-8.

Bishburg E, Sunderam G, Reichman LB, Kapila R. Central nervous system tuberculosis with the acquired immunodeficiency syndrome and it related complex. Ann Intern Med 1986;105:210-3.

Yechoor VK, Shandera WX, Rodriiguez P, Cate TR. Tuberculous meningitis among adults with and without HIV infection. Experience in urban public hospital. Arch Intern Med 1996;156: 1710-6.

Satishcahndra P, Nalini A, Gourie- Devi M, Khanna N, Santosh V, Ravi V, et al. Profile of neurologic disorders associated with HIV/ AIDS from Bangalore, south India [1989-96]. Indian J Med Res 2000;111:14-23.

Dube MP, Holtom PD, Larsen RA. Tuberculous meningitis in patients with and without human immunodeficiency virus infection. Am J Med 1992;93:520-4.

Verdon R, Chevret S, Laissy JP, Wolff M. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis 1996;22:982-8.

Karstaedt AS, Valtchanova S, Barriere R, Crewe- Brown HH. Tuberculous meningitis in South African urban adults. QJM 1988;91:743-7.

Whiteman M, Espinoza L, Post MJ, Bell MD, Falcone S. Central nervous system tuberculosis in HIV infected patients: Clinical and radiographic findings. AJNR Am J Neuroradiol 1995;16:1319-27.


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