VITAMIN D STATUS AND ITS ASSOCIATION WITH SERUM BETA HCG AND SERUM AFP IN SECOND TRIMESTER OF PREGNANCY FOR PREDICTING PREECLAMPSIA

Dr Srabani Ghosh, Dr Lekha Biswas, Dr Debes Ray

Abstract


Objectives Investigate the association of second trimester β-HCG, AFP, Vitamin D concentration with subsequent development of Preeclampsia.

 Material & Methods:  β-HCG AFP, Vitamin D, Waist circumference were measured in 200 Pregnant women in 13th-20th wks. of gestation fulfilling the inclusions criteria These tests were measured by CLIA method by Advia Centaur XP machine.

RESULTS

Serum vitamin D levels (second trimester) in pregnancies with preeclampsia are found to be significantly lower than those in pregnancies with normal outcome (p value<0.001). Percentage of cases with high serum AFP levels in second trimester (MOM>2) is found to be significantly higher in the pregnancies with preeclampsia than those in pregnancies with normal outcome (p value <0.001) Percentage of preeclampsia (as outcome) is significantly higher in cases with high serum βHCG (MOM>2) than those with low serum βHCG (MOM<2) in second trimester (p value <0.001).   There is significant positive correlation of serum βHCG with serum AFP levels (second trimester) in pregnancies with preeclampsia.

Conclusion

Our study shows that serum β-HCG and AFP levels in second trimester of pregnancy has predictive value for developing Preeclampsia. Also, vitamin D may have a decisive role in predicting pre-eclampsia and has a potential to emerge as an independent marker of developing pre-eclampsia.


Keywords


SERUM β HCG, AFP AND VIT D, PRE-ECLAMPSIA

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References


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