EFFECT OF THYROID HORMONE ON HbA1c LEVELS IN PATIENTS WITH NEWLY DETECTED HYPOTHYROIDISM

Dr Raghunandan Meena, Dr Subhita Choudhary, Dr Khushala Ram Choudhary

Abstract


Introduction: HbA1c is an important parameter in diagnosis of diabetes. However, Glycated hemoglobin (HbA1c) may
not accurately reflect the level of glycemia in conditions of altered erythrocyte turnover.
Objective: to determine HbA1c levels in non-diabetic patients with newly detected hypothyroidism and to determine
the effect of thyroid hormone replacement therapy on HbA1c levels.
Material and method: A prospective study was carried out July 2019 to December 2019 in the Department of Medicine
in a tertiary care teaching institute in Jhalawar, District, Rajasthan. Total 128 Patients with newly detected hypothyroidism
were included in this study. Thyroid hormone replacement was prescribed for 3 months to all patients.Paired t-test (2-
tailed) was used to compare means of different parameters before and after the restoration of euthyroid state.
Results: Thyroid replacement therapy showed a statistically significant difference in haemoglobin level (p=0.008),
thyroid profile (p=0.001) and HbA1c level (p=0.007) of study participants. There was a significant negative correlation
between glycosylated haemoglobin and serum T4 levels (r =-0.42, p <0.05). Serum TSH level shows significantly positive
correlation with glycosylated haemoglobin (r = 0.26, p <0.05).
Conclusion: The study revealed a statistically significant reduction in mean HbA1c after thyroid replacement therapy
which concludes that correction of hypothyroid states was associated with fall in HbA1c levels. A significantly positive
correlation was found between Serum TSH level and glycosylated hemoglobin. It implies that that thyroid hormone
affects HbA1c values.


Keywords


Thyroid hormone, Hypothyroidism, HbA1c, TSH.

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