SQUAMOUS CELL CARCINOMA OF LEFT HAND IN A PATIENT WITH EPIDERMOLYSIS BULLOSA DYSTROPHICA- A CASE REPORT

Dr. F. Benjith Daniel, Dr. K. Chinthinidhi, Dr. G. Srinath, Dr. K. Kuberan

Abstract


INTRODUCTION :
Epidermolysis bullosa (EB) refers to a group of hereditary mechanobullous
disorders ,most of them are associated with chronic scarring.
Several forms of this disease have been reported with cutaneous
malignancy. Squamous cell carcinoma is a well recognised
complication that develops from various cicatrising and ulcerative
dermatoses. We report a case of Squamous cell carcinoma in a patient
with Epidermolysis bullosa dystrophica.


Full Text:

PDF

References


l. Eady RAJ, Tidman M. Diagnosing epidermolysis bullosa. BrJ Dermatol 1983: 108: 621

Heagcrty AHM, Kennedy AR, Leigh 1M, P, Eady RAJ. Identification of an epidermal basement membrane defect in recessive dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis. Br J Dermatol 1986: 1 15: 125.

Schofield 0M V, Fine J-D, Verrando P, Heagcrty AHM Ortonne J-P, Eady RAJ. GB3 monoclonal antibody for the diagnosis of junctional epidermolysis bullosa: results of a multicenter study. J Am Acad Dermatol 1990: 23: 1078.

Tidman M, Atherton D, Eady RINJ. Squamous cell carcinoma as a complication of dystrophic epiclermolysis bullosa. J R soc Med 1984: suppl 4: 37.

McGrath JA, Schofield OMV, Mayou B], McKee PH, Eady RAJ. Metastatic squamous cell carcinoma resembling angiosarcoma complicating dystrophic epidermolysis bullosa. Dermatologica 1991: 182: 235.

Leigh M, Eady RAJ, I-leagerty AH M, Purkis PE, Whitehead PA, Burgcson RE. Type VI I collagen is a normal component of epidermal basement mennbrane which shows altered expression in recessive dystrophic epidermolysis bullosa..J Invest Dermatol 1988: 90: 639.

Eady RAJ. Transmission electron microscopy. In: Skerrow D, Skcrrow C], cds. Methods in skin research. New York: Wiley 1985: l.

Monk BE, Pembroke AC. Epidermolysis bullosa with squamous cell carcinoma. Clin Exp Dermatol 1987: 12: 373.

Parker SC, Schofield MV, Black MM, Eady RAJ. Non. lethal junctional epidermolysis bullosa complicated by squamous cell carcmoma. In: Prics(lcy GC, "lidman M Weiss J B, Eady RAJ, cds. Epidermolysis bullosa: a cotuprehcnsivc rcvl(tw of classification, management and laboratory studies. Dystrophic Epidermolysis Bullosa Research Association, Berkshire, UK. 1990: 103.

Crikelair G F, Hochn R, Domonkos AN, Binkert B. Skin homografts in epidermolysis bullosa dystrophica. Plast Reconstr Surg 1970: 46: 89.

Wechsler HL, Krugh 11], AN, Scheen SR, Davidson SL. Polydysplastic epidermolysis bullosa and development of epidermal neoplasms. Arch Dermatol 1970: 102: 374.

Pellicano R, Fabrizi G, Cerimclc D. Multiple keratoacanthomas and junctional epidermolysis bullosa. Arch Dermatol 1990: 126: 305.

Cornelius CE, Shelley VVB. Syndactylism, dyschromia, and the arsenical dilemma. Arch Dermatol 1968: 98: 107.

Recd WB, College J, Francis MJO, Zachariac H, Mohs F, Sher MA, Sneddon 1B. Epidermolysis bullosa dystrophica with epidermal neoplasms. Arch Dermatol 1974: 1 10: 894.

Carapeto FJ, Pastor JA, Martin J, Agurruza J. Recessive dystrophic epidermolysis bullosa and multiple squamous cell carcinomas. Dermatological 1982: 165: 39.


Refbacks

  • There are currently no refbacks.