WILMS TUMOR- A 10 YEAR INSTITUTIONAL REVIEW AT GMCH NAGPUR

Dr. Ashok Kumar Diwan, Dr. Saurabh Meshram, Dr. Subeera Khan

Abstract


BACKGROUND- Wilms tumor also known as nephroblastoma has multimodality treatment approach leading to good prognostic outcomes
in this disease, still in India the overall survival is poor. Also,there is paucity of data about the epidemiology, pathology, treatment and
prognosis of the disease from India, therefore we conducted a retrospective analysis of the multimodality treatment & report the outcomes of
Wilms tumor at department of radiation oncology at GMCH Nagpur over 10 yrs
MATERIAL AND METHODS- 104 clinico-radiologically and histopathologically proven patients registered of which 68 were evaluated for
Demographic Data,Clinico-pathologic Profile, Treatment related data and Survival registered from 2007-2017 at the dept of radiation therapy and
oncology GMCH Nagpur
RESULTS- Total 104 patients of which 53 were males (50.96%) and 51 were females (49.03%) with mean age at the time of diagnosis
4.4±0.84yrs. Radical Nephrectomy was performed in 62% of cases, 25% were metastatic & 13% came in locally advanced stage with poor general
condition at the time of presentation. Favourable histology findings were found in 38 (56.71%) and unfavourable were 29 (focal + diffuse + CCK +
RTK) (42.85%). 5 yrs overall survival rate stage I 90% stage II 80% stage III 75%stageIV 45%, the 5 yrs overall survival rate was found to be
74.25%.
CONCLUSION- the children who presented at our institute came in late stages; most common presentation was in stage III followed by stage IV.
The 5 year &10-year survival rate & event free survival rate was very low compared to the other studies. The probable reason for this may be due to
the presentation of patients in late stages and poor general condition causing difficulty in delivering the optimum treatment


Keywords


Wilms Tumour, Histology, Radical Nephrectomy, Outcome.

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References


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