EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LANSOPRAZOLE IN ADULT MALE ALBINO RATS

Dr. Saraswathi. S, Dr. Raadhika. K., Dr. Malathi. M., Dr. Shanthi. M.

Abstract


Back ground- Inflammation plays a major role in many diseases such as osteoarthritis. Lansoprazole,a Proton pump inhibitor might have antiinflammatory
effect due to its chemical structure.
Objective- To evaluate the anti inflammatory effect of Lansoprazole in adult male albino Rats.
Methodology- The anti-inflammatory effect of graded doses of T.Lansoprazole (5 mg/kg ,10 mg/kg) was evaluated by 1% Carrageenan induced
paw edema and measuring it using Plethysmometer.It was compared with the standard drug Aspirin. The values obtained were expressed as mean ±
S.D. and percentage inhibition calculated. Statistical analysis of difference between groups was carried out using one- way Analysis of
variance(ANOVA).Probability (P) value of < 0.05 was taken as the level of statistical significance.
Result - T.Lansoprazole at both doses of 5 mg and 10 mg produced significant inhibition of paw edema at a P-value of < 0.01.
Conclusion- T.Lansoprazole had anti inflammatory property both at 5mg/kg and 10 mg/kg dose and it was comparable to that of T.Aspirin
300mg/kg .


Keywords


Anti-inflammatory,Lansoprazole,Carrageenan,Aspirin,Plethysmometer.

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References


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