STUDY OF VITAMIN D3 DEFICIENCY IN HYPOTHYROIDISM PATIENTS
Abstract
Objectives: This present study was to evaluate the association of various parameters like TSH levels, FT4, FT3 and anti TPO levels with the levels of vitamin D3 in hypothyroidism patients. Methods: Detail history clinical examinations and relevant investigations were performed to all subjects. Sample was collected for the estimation of serum TSH, FT3, FT4, Anti-TPO and Vitamin D3 levels. Under complete aseptic conditions venous blood was withdrawn from antecubital vein. Levels of FT3, FT4, TSH, Anti-TPOAb and Vitamin D3 were estimated using fluorescence array. Results: Data was analyzed by using SPSS version 26 software. One sample statistical methods analysis was used. Mean ± standard deviation were calculated. P value was taken less than or equal to 0.05 for significant differences (p ≤ 0.05). Conclusions: Hypothyroidism patients had significantly increased TSH levels. Most of the patients had decreased vitamin D3 levels. And the patients who had increased TSH levels were associated with decreased vitamin D3 levels. Hence, all the patients of hypothyroidism should be assessed for the levels of vitamin D3. And accordingly vitamin D3 supplementation should be advised for early management and treatment of vitamin D3 deficiency in hypothyroidism patients.
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M. F. Holick and T. C. Chen, “Vitamin D deficiency: a worldwide problem with health consequences,” +e American Journal of Clinical Nutrition, vol. 87, no. 4, pp. 1080S–1086S, 2008.
Makariou S, Liberopoulos EN, Elisaf M, Challa A, 2011 Novel roles of vitamin D in disease: What is new in 2011? Eur J Intern Med 22:355-362.
Khadilkar AV. Vitamin D deficiency in Indian adolescents. Indian Paediatr 2010;47:756-7.
Scragg R, Sowers M, Bell C. Serum 25 hydroxyvitamin D, diabetes and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004;27:2813-8.
Pittas AG, Lau J, Hu FB et al. The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta analysis. J Clin Endocrinol Metab 2007;92:2017- 29.
Forman JP, Giovannucci E, Holmes MD et al. Plasma 25 hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007;49:1063-9.
EURODIAB Study Group. Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia 1999; 42: 51–54.
Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013; 36: 1422–1428.
Lopez ER, Zwermann O, Segni M, Meyer G, Reincke M, Seissler J et al. A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol 2004; 151: 193–197.
Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006; 114: 577–583.
McDonnell DP, Pike JW, O'Malley BW. The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor. J Steroid Biochem 1988; 30: 41–46.
Tamer G, Arik S, Tamer I, Coksert D. Relative vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid 2011; 21: 891–896.
Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine 2012; 42: 739–741.
Shoenfeld Y, Selmi C, Zimlichman E, Gershwin ME. The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun 2008;31:325–330.
Hetzel BS, Porter BJ, Dulberg EM. The iodine deficiency disorders: nature, pathogenesis and epidemiology. World Rev Nutr Diet 1990;62:59–119.
Swati Sonawane, Bhagyashri Bora, D.Y. Shrikhande, Sahil Bansal, Prabhat Kumar. Vitamin D deficiency and its association with thyroid diseases. International Journal of Contemporary Medical Research 2017;4(8):1765-1767.
Hodgkin P, Kay GH, Hine PM. Vitamin D deficiency in Asians at home and in Britain. Lancet 1973;2:167-71.
Harynarayan CV, Joshi SR. Vitamin D status in India- Its implications and remedial measures. J Assoc Physicians India 2009;57:40-8.
Aljohani NJ, Al Daghri NM, Al‑Attas OS, Alokail MS, Alkhrafy KM, Al‑Othman A, et al. Differences and associations of metabolic and vitamin D status among patients with and without sub‑clinical hypothyroid dysfunction. BMC Endocr Disord 2013;13:31.
Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine 2012;42:739‑41.
Mackawy AM, Al Ayed BM, Al Rashidi BM. Vitamin d deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013(7); 267:75.
Chaudhary S, Dutta D, Kumar M, Saha S, Mondal SA, Kumar A, et al. Vitamin D supplementation reduces thyroid peroxidise antibody levels in patients with autoimmune thyroid disease: An open‑labeled randomized controlled trial. Indian J Endocrinol Metab 2016;20:391‑8.
Alrefaie Z, Awad H. Effect of vitamin D3 on thyroid function and de‑iodinase 2 expression in diabetic rats. Arch Physiol Biochem 2015;121:206‑9.
Yamashita H, Noguchi S, Takatsu K, Koike E, Murakami T, Watanabe S, et al. High prevalence of vitamin D deficiency in Japanese female patients with Graves’ disease. Endocr J 2001;48:63‑9.
Wang J, Lv S, Chen G, Gao C, He J, Zhong H, et al. Meta‑analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015;7:2485‑98.
Talaei A, Ghorbani F, Asemi Z. The effects of vitamin D supplementation on thyroid function in hypothyroid patients: A randomized, double‑blind, placebo‑controlled trial. IndianJ Endocr Metab 2018;22:584-8.
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