A STUDY OF RHEUMATOLOGICAL MANIFESTATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ITS RELATION TO GLYCEMIC CONTROL
Abstract
Background: Type 2 Diabetes mellitus is usually associated with several rheumatological manifestations that cause significant morbidity. This study was conducted to find the prevalence of rheumatological manifestations in patients with type 2 diabetes and its relation to glycemic control.
Methods: This was a cross-sectional study done in 120 type 2 diabetic cases and 60 age and sex-matched non-diabetic controls in Katuri Medical College & Hospital for one year. Subjects were examined for various rheumatological manifestations and all the necessary investigations were done.
Results: Rheumatological manifestations were seen in 42.5% of patients with type 2 diabetes mellitus compared to 26.6% in non-diabetic subjects. Limited joint mobility was the most common manifestation seen in 29.4% of diabetic group followed by Periarthritis of shoulder (20.8%), Carpal tunnel syndrome (15.83%) and Dupuytren’s contracture (14.16%). Majority of the patients had HbA1c levels between 8.1 to 10%.
Conclusion: Rheumatological manifestations are more prevalent in people with type 2 diabetes than those without diabetes. Limited joint mobility and periarthritis of shoulder are the most common rheumatological manifestations. Usually, poor glycemic control is associated with an increase in rheumatological manifestations.
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Ramachandran A, Das AK, Joshi SR, Yajnik CS, Shah S, Kumar KMP: Current status of Diabetes in India and Need for Novel Therapeutic Agents. Journal of Physicians of India.2010; 58:7-9).
Egede LE. Diabetes, major depression, and functional disability among US adults. Diabetes Care 2004; 27: 421–428.
Stahl S, Kanter Y, Karnielli E. Outcome of trigger finger treatment in diabetes. J Diabetes Complications 1997;11:287-90.
Bridgman JF. Periarthritis of the shoulder and diabetes mellitus. Ann Rheum Dis 1972;31:69-71.
Smith LL, Burnet SP, McNeil JD. Musculoskeletal manifestations of diabetes mellitus. Br J Sports Med 2003;37:30-5.
Lebiedz-Odrobina D, Kay J. Rheumatic manifestations of diabetes mellitus. Rheum Dis Clin North Am 2010;36:681-99.
Fitzcharles MA, Duby S, Waddell RW, Banks E, Karsh J. Limitation of joint mobility (cheiroarthropathy) in adult noninsulin-dependent diabetic patients. Ann Rheum Dis 1984;43:251-4.
Mathew AJ, Nair JB, Pillai SS. Rheumatic musculoskeletal manifestations in type 2 diabetes mellitus patients in South India. Int J Rheum Dis. 2011;14:55–60.
S Coley, RD Situnayake, MJ Allen.Compartment syndrome, stiff joints, and diabetic cheiroarthropathy. Ann Rheum Dis. 1993 Nov; 52(11): 840.
Rosenbloom AL, Silverstein JH. Connective tissue and joint disease in diabetes mellitus. Endocrinol Metab Clin North Am 1996;25:473-83.
Goldberg BA, Scarlat MM, Harryman DT 2nd. Management of the stiff shoulder. J Orthop Sci 1999;4:462-71.
Fitzgibbons PG, Weiss AP. Hand manifestations of diabetes mellitus. J Hand Surg Am 2008;33:771-5.
Resnick D, Niwayama G. Diagnosis of bone and joint disorders. 2nd ed. Philadelphia: WB Saunders; 1988:1563-615.
Cagliero E, Apruzzese W, Perlmutter GS, Nathan DM. Musculoskeletal disorders of the hand and shoulder in patients with diabetes mellitus. Am J Med.2002;112(6):489-92.
Jacob Antony, Regi David Sam. Musculoskeletal Complications of Diabetes and Relation to Glycemic Control. Journal of medical science and clinical research October 2017: Vol 5(10):29073-29079.
Gurinder Mohan, Narotam Bhalla, Ranjeet Kaur, Jasleen Kaur Kohli. “Rheumatological Manifestations of Type 2 Diabetes Mellitus” Journal of Evolution of Medical and Dental Sciences 2014; Vol. 3 (3); 582-588.
Sumesh Raj, G. V. Rajan, Rajesh Vijayan, Reshma Sugathan. Rheumatological manifestations of type 2 diabetes and its relationship to glycemic control and duration of diabetes. Sahel Medical Journal January-March 2014: Vol 17 ( 1).12-14.
Tapas Kumar, Adwitiya Das. Rheumatological Manifestations in Diabetes Mellitus: Distribution And Associated Factors.IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) June 2016. Vol 15(6).:51-54.
Ramchurn N, Mashamba C, Leitch E, Arutchelvam V, Narayanan K, Weaver J, Hamilton J, Heycock C, Saravanan V, Kelly C. Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes. Eur J Intern Med. 2009; 20:718-21.
Durgaprasad M. Kabade, Afaq Ahmed, Prashanth Kumar M. Study of Rheumatological Musculo-Skeletal Manifestations among Patients with Controlled and Uncontrolled Type II Diabetes Mellitus at a Tertiary Care Centre of North Karnataka, India.International Journal of contemporary medical research.Jan 2017.Vol 4(1):52-57.
Aydeniz A, Gursoy S, Guney E. Which Musculoskeletal Complications are most frequently seen in Type 2 Diabetes mellitus? The Journal of International Medical Research. 2008; 36:505-11.
Mathew AJ, Nair JB, Pillai SS. Rheumatic musculoskeletal manifestations in type 2 diabetes mellitus patients in South India. Int J Rheum Dis. 2011; 14:55–60.
Sarkar P, Pain S, Sarkar RN, Ghosal R, Mandal SK, Banerjee R. Rheumatological manifestations in diabetes mellitus. J Indian Med Assoc. 2008; 106:593-5.
Arkkila PET, Kantola IM, Viikari JSA, Rönnemaa T. Shoulder capsulitis in type I and II diabetic patients: association with diabetic complications and related diseases. Ann Rheum Dis .1996; 55:907-14.
Balci N, Balci MK, Tuzuner S. Shoulder adhesive capsulitis and shoulder range of motion in type II diabetes mellitus: association with diabetic complications. J Diabetes Complications.1999;13: 135-40.
Sturmer T, Brenner H, Brenner RE, Gunther KP. Non-insulin dependent diabetes mellitus (NIDDM) and patterns of osteoarthritis: The Ulm Osteoarthritis study. Clin Rheumatol. 2001; 30(3):169-171.
Renard E, Jacques D, Chammas M, Poirier JL, Bonifacj C, Jaffiol C et al. Increased prevalence of soft tissue hand lesions in type 1 and type 2 diabetes mellitus: various entities and associated significance. Diabet Metab. 1994; 20(6): 513-21.
Douloumpakas I, Pyrpasopoulou A, Triantaafyllou A, Sampanis Ch, Aslanidis S. Prevalence of musculoskeletal disorders in patients with type 2 diabetes mellitus: a pilot study. Hippokratia. 2007; 11:216-8
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