EFFECT OF SITAGLIPTIN ON LIPID PROFILE OF TYPE 2 DIABETES MELLITUS PATIENTS

Dr. Priyanka Malik, Dr. Yogesh Garg, Dr.Navpreet Kaur

Abstract


Background: Sitagliptin is a dipeptidyl-peptidase inhibitor (DPP-4 inhibitor) Like other DPP-4 inhibitors its action is mediated by increasing levels of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP).  The study was aimed to evaluate the effect of sitagliptin on lipid profile in patients with type-2 Diabetes Mellitus at 0 level and after 16 weeks of treatment with sitagliptin.

Material and Methods: A prospective study comprising 70 diagnosed cases of type 2 diabetes mellitus was carried out. These patients were put on sitagliptin 100 mg OD for 16 weeks and venous blood samples were taken at 0 level and after 16 weeks.

 Results The decrease in mean serum cholesterol levels at 0 week and 16 weeks was 17.84mg/dl (6.64%) . The change in mean serum triglycerides level was 42.30mg/ dl (18.75%). On Statistical analysis, the reduction in serum cholesterol levels and in serum triglycerides levels in total number of patients was highly significant (p<0.001). The mean increase in serum high density lipoprotein cholesterol (HDL-C) level was 0.08 mg/dl and mean% increase in HDL-C level was 0.25% at 4 months from baseline. On statistical analysis the increase in mean serum HDL-C level in study group was non-significant (p 0.223).

Conclusions: The study concludes that Sitagliptin represents a substantial advance in antidiabetic therapy and it helps in improving the lipid profile of type 2 diabetes patients.


Keywords


Dipeptidyl-peptidase inhibitor (DPP-4 inhibitor), Diabetic Profile,,Lipid Profile, Sitagliptin, Type 2 Diabetes Mellitus

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References


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