A STUDY OF PREVALENCE OF THYROID DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME
Abstract
Introduction : Metabolic syndrome is generally characterized as a clustering of the abnormal levels of blood lipids (low High Density Lipoprotein (HDL) and high triglycerides), impaired fasting glucose, elevated blood pressure and excess abdominal obesity.
Objectives : To study the prevalence and type of thyroid dysfunction in a diagnosed case of metabolic syndrome.
Material And Method:
A complete physical and systemic examination was performed including CBC, RFT, Blood Glucose profile, Thyroid examination, complete urine. X-ray chest, USG-KUB, 2D-echo was performed in all cases.
Results : The percentage of sub clinical hypothyroid was 21% and overt hypothyroid was 9%. Subclinical hypothyroidism and overt hypothyroidism were present in 26.66% and 11.66% of females and in 12% and 5% of males respectively. None of the patient had subclinical or overt hyperthyroidism.
Conclusion : It can be concluded from the present study that sub clinical hypothyroidism and overt hypothyroidism is significantly associated with metabolic syndrome, especially females with metabolic syndrome have a higher prevalence of thyroid dysfunction which predisposes them to cardiovascular events. Therefore, we recommend the routine screening of the thyroid function in females with metabolic syndrome.
Full Text:
PDFReferences
Church TS. Metabolic syndrome and Diabetes, Alone and in Combination, as predictors of cardiovascular disease mortality among Men. Diabetes Care, 2009; 32(7) : 1289-1294.
Grundy S M. Diagnosis and Management of the Metabolic Syndrome; An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement, 2005; 112: 2735-2752.
Tkac I. Metabolic syndrome in relationship to type 2 diabetes and atherosclerosis. Diabetes Res Clin Pract, 2005; 68(suppl): S2-9.
Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocr J, 2007; 54: 71-76.
Jayakumar RV, Nisha B, Unnikrishnan AG, Nair V, Kumar H. Thyroid status in metabolic syndrome - a clinical study. Thyroid Research and Practice, 2010; 366- 370.
Ghanshyam Palamaner Subash Shantha, Anita A Kumar, Vijay Jeyachandran, Deepan Rajamanickam, K Rajkumar, Shihas Salim, Kuyilan Karai Subramanian and Senthilkumar Natesan. Department of General Medicine, Sri Ramachandra University, Chennai, India. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid Research 2009: 2:2 doi:10.1186/1756-661422.
Elisabeth H A, Huibert AP P, Visser JT, Drexhage HA, Hofman A and Jacqueline CVW. Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study. Annals of Internal Medicine, 2000; 132(4):270-278.
Bakker SJL, Maaten JC T, Popp-Snijders C, Slaets JPJ, Heine RJ, Gans ROB. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J Clin Endocrinol Metab, 2001; 86: 1206-11.
Bjorn O A, Svold, Lars J Vatten, Tom IL, Nilsen and Trine Bjoro. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. European Journal of Endocrinology (2007); 156: 181-186.
Elizabeth NP. Hypothyroidism and dyslipidaemia: Modern concepts and approaches. Current Cardiology Reports, 2004; 6(6): 451-456, DOI: 10.1007/s 11886- 004-0054-3.
Refbacks
- There are currently no refbacks.