A STUDY OF RADIOLOGICAL AND PATHOLOGICAL CORRELATION OF THYROID MASSES.

Dr. Ravindra R. Alurwar, Dr. Pallavi Alurwar, Dr. Pramod Wavale, Dr. Ashish Patil, Dr Omkar Kale, Dr Allam Prabhu

Abstract


Objective. To determine the role of radiological-pathological correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules. Methods. This retrospective study included 307 nodules 1 cm or larger in 302 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ultrasound (US) or FNA. We compared the risk of malignancy of nodules classified into subgroups according to the initial US features and imaging-cytology correlation. Results. Among included nodules, 7 nodules were proven to be malignant (2.3%) in follow-up FNA or surgery. When a thyroid nodule had discordant US findings on image review after having benign FNA results, malignancy rate increased to 23.3%, significantly higher than that of nodules with suspicious US features (P < 0.001). Conclusions. Repeat FNA can be effectively limited to patients with cytologically benign thyroid nodules showing discordance in imaging-cytology correlation after initial biopsy, which reduces unnecessary repeat aspirations.


Keywords


thyroid, radiology

Full Text:

PDF

References


Cooper DS, Doherty GM, Haugen BR, et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):1167–1214.

Gharib H, Papini E, Paschke R, et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. Journal of Endocrinological Investigation. 2010;33(supplement 5):51–56.

Wang C-CC, Friedman L, Kennedy GC, et al. A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid. 2011;21(3):243–251.

Al-Hureibi KA, Al-Hureibi AA, Abdulmughni YA, Aulaqi SM, Salman MS, Al-Zooba EM. The diagnostic value of fine needle aspiration cytology in thyroid swellings in a University Hospital, Yemen. Saudi Medical Journal. 2003;24(5):499–503.

Gabalec F, Čáp J, Ryška A, Vašátko T, Ceeová V. Benign fine-needle aspiration cytology of thyroid nodule: to repeat or not to repeat? European Journal of Endocrinology. 2009;161(6):933–937.

Chehade JM, Silverberg AB, Kim J, Case C, Mooradian AD. Role of repeated fine-needle aspiration of thyroid nodules with benign cytologic features. Endocrine Practice. 2001;7(4):237–243.

Kwak JY, Koo H, Youk JH, et al. Value of US correlation of a thyroid nodule with initially benign cytologic results. Radiology. 2010;254(1):292–300.

Kwak JY, Jung I, Baek JH, et al. Thyroid imaging reporting and data system for ultrasound features of thyroid nodules: multicentric korean retrospective study. Korean Journal of Radiology. 2013;14(1):110–117.

Bassett LW, Mahoney MC, Apple SK. Interventional breast imaging: current procedures and assessing for concordance with pathology. Radiologic Clinics of North America. 2007;45(5):881–894.

Kim E-K, Cheong SP, Woung YC, et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. The American Journal of Roentgenology. 2002;178(3):687–691.

Anderson L, Middleton WD, Teefey SA, et al. Hashimoto thyroiditis: part 1, sonographic analysis of the nodular form of Hashimoto thyroiditis. The American Journal of Roentgenology. 2010;195(1):208–215.

Moon W-J, Baek JH, Jung SL, et al. Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean Journal of Radiology. 2011;12(1):1–14.

Yeh MW, Demircan O, Ituarte P, Clark OH. False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma. Thyroid. 2004;14(3):207–215.

Bakhos R, Selvaggi SM, DeJong S, et al. Fine-needle aspiration of the thyroid: rate and causes of cytohistopathologic discordance. Diagnostic Cytopathology. 2000;23(4):233–237.

Raab SS, Vrbin CM, Grzybicki DM, et al. Errors in thyroid gland fine-needle aspiration. The American Journal of Clinical Pathology. 2006;125(6):873–882


Refbacks

  • There are currently no refbacks.