ROLE OF MICROVESSEL DENSITY IN TRANSITIONAL CELL CARCINOMAS OF URINARY BLADDER
Abstract
Introduction: Bladder carcinoma is a neoplasm arising from the lining transitional epithelium. More than 90% of bladder cancer cases are urothelial (transitional cell) carcinomas. Out of various prognostic factors, grade and stage are important. The non-muscle-invasive disease in spite of lower stage has a high recurrence of about 50–70% of the patients. Thus additional Prognostic factors play a role in determining the recurrence. Microvessel density is one such factor which is associated with recurrence. In this study, microvessel density is calculated using CD 34 and compared with standard clinicopathological variables.
Materials and Methods: This study is an observational study of randomly selected 50 cases of Transitional cell carcinomas of urinary bladder that were submitted for histopathological evaluation during the period of 2 years in our institution. The slides were reviewed from the archive and histopathological parameters assessed. Immunohistochemical analysis was done with CD 34 and microvessel density (MVD) was calculated by counting the hot spots in 200X power. The results were compared with clinicopathological parameters.
Results: The mean MVD values showed statistically significant increase in male gender and non-papillary tumours. The increase shows no statistical significance in multiple tumours, high grade and in recurrent tumours. The mean MVD values showed a decrease with increasing stage, size and infiltration and this association was statistically insignificant.
Conclusion: Though MVD values were reducing with stage, patients with high microvessel density (>50) presented with recurrence. Thus evaluating microvessel density can be an adjuvant factor in determining the prognosis of the patients.
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