ROLE OF CANCER ANTIGEN 125(CA 125) AND LIPID PROFILE IN OVARIAN CARCINOMA PATIENTS.

Abstract

Background: The term "ovarian cancer" includes several different types of cancer that arise from cells of the ovary, most commonly, tumors arise
from the epithelium or lining cells of the ovary. CA-125 is the most frequently used biomarker for ovarian cancer detection. One of the most
common and heavily researched screening tools today is elevation of the blood protein CA-125. Robert Bast (1980) first discovered the biomarker
and he believes that although the CA-125 blood test is at par with mammography in terms of cost-effectiveness and potential years of life. Ovarian
cancer risk is positively associated with higher consumption of dietary cholesterol and eggs, and inversely associated with a higher intake of
vegetables. High consumption of fats may increase circulating estrogen levels, thus increasing the possibility of cell damage and proliferation that
is responsible for cancerous growth.
Material & methods: The present study was conducted at GEETANJALI MEDICAL COLLEGE AND HOSPITAL, Udaipur (Rajasthan). Total
100 cases (females) attending the obstetrics and gynecology department for some gynecological and other problem were selected for this study
between the age of 40-60 years, who were attending cancer centre at GEETANJALI MEDICAL COLLEGE AND HOSPITAL, Udaipur
(Rajasthan).
GROUP I: - It consisted of healthy females control subjects (n=50) .By routine examination and tests, we ensured that all the subjects were healthy
and there were no signs and symptoms or history of ovarian tumor and diseases.
GROUP II: - It consisted of ovarian cancer females subjects (n=50) with a history of ovarian tumor.
Results: Higher level of cholesterol ,LDL , VLDL and CA-125 are found in ovarian cancer.
Conclusion: The present study we highlights the importance and role of serum CA 125 in diagnosis, prognosis and recurrence of the disease. The
study shows that serum level of CA 125 was elevated (more than 35 U/ml) in 48 (96%) patients of ovarian cancer and indicates that CA 125 has high
sensitivity for diagnosis of ovarian cancer. The study shows that serum level of cholesterol, LDL, VLDL was elevated in patients of ovarian cancer
while low level of HDL are found in ovarian cancer patients.