HIGH SELENIUM LEVELS IN PARKINSON'S DISEASE? A STUDY FROM CENTRAL KERALA

Asha Cherian Joseph, J. K. Mukkadan, Ashok Menon

Abstract


Oxidative stress on dopaminergic neurons in the substantia nigra caused by cytotoxic free radicles generated during oxidative metabolism of dopamine is hypothesized to be one of the etiopathogenic mechanisms of Parkinson’s disease (PD). Glutathione peroxidase (GPX) plays an important role in reducing peroxide-mediated stress. Selenium, a trace element, is a component of GPX and assists in this process. The aim of this case-control study was to analyze serum Selenium levels among PD patients in central Kerala. Serum selenium was estimated using Inductively Coupled Plasma-Mass Spectrometry in 30 patients and 30 controls. Serum Selenium levels were found to be elevated in PD patients as compared to controls.  


Keywords


Parkinson’s disease, Dopaminergic neurons, Oxidative stress, Selenium

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References


Kempster. A Peter, Hurwitz Brain, Lees. J Andrew. A new look at James Parkinson’s Essay on the Shaking Palsy. Neurology. 2007;69(5):482-485.

Tysnes OB, Storstein A. Epidemiology of Parkinson’s disease. Journal of Neural Transmission 2017;124: 901-905.

De Lau LM., Breteler MM. Epidemiology of Parkinson’s disease. Lancet Neurology 2006;5:525-35.

Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR. Oxidative stress and Parkinson's disease. Front Neuroanat. 2015;9:91.

Tinggi U. Selenium: its role as antioxidant in human health. Environ Health Prev Med 2008;13(2):102-108.

Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, et al. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 1994;36:348-355.

Martin H.L, Teismann P. Glutathione--a review on its role and significance in Parkinson's disease. FASEB J 2009;23(10):3263-3272.

Nikam S, Nikam P, Ahaley S K, Sontakke AV. Oxidative stress in Parkinson’s disease. Indian Journal of Clinical Biochemistry 2009;24(1):98-101.

Ahmed SS, Santosh W. Metallomic profiling and linkage map analysis of early Parkinson's disease: a new insight to aluminum marker for the possible diagnosis. PLoS One 2010;5(6):e11252.

Lavanya PD, Reddy BS, Rao DA, Sattar SA, Rao SB, Raju AS. Trace Elemental Analysis of Blood Serum Samples of Patients Afflicted with Parkinson’s disease. International Journal of Bioassays 2014;3:1858–1865.

Zhao HW, Lin J, Wang XB, Cheng X, Wang JY, Hu BL, et al. Assessing Plasma Levels of Selenium, Copper, Iron and Zinc in Patients of Parkinson’s disease. PLoS One 2013;8(12): e83060.

Hemmati-Dinarvand M, Taher-Aghdam AA, Mota A, Zununi Vahed S, Samadi N. Dysregulation of serum NADPH oxidase1 and ferritin levels provides insights into diagnosis of Parkinson’s disease. Clin Biochem 2017;50(18):1087–1092.

Fathi F, Mehrpour M, Arefi Oskouie A, Fathi S, Sohrabadeh K, Rostami Nejad M. The role of selenium in Parkinson’s disease. Research in Medicine 2013;37(2):90-92.

Younes-Mhenni S, Aissi M, Mokni N, Bouatay B, Chebel S, Frih-Ayed M. et al. Serum copper, zinc and selenium levels in Tunisian patients with Parkinson’s disease. La Tunisie medicale 2013;91: 402–405.

Gellein K, Syversen T, Steinnes E, Nilsen T I L, Dahl OP, Mitrovic, S. et al. Trace elements in serum from patients with Parkinson's disease- a prospective case-control study: the NordTrøndelag Health Study (HUNT).Brain Research 2008;1219:111-115.

Shahar A, Patel KV, Semba RD, Bandinelli S, Shahar DR, Ferrucci L. et al. Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed. Movement disorders 2010;25(12):1909-1915.

Qureshi GA, Qureshi AA, Memon SA, Parvez SH. Impact of selenium, iron, copper and zinc in on/off Parkinson’s patients on L-dopa therapy. J Neural Transm 2006;71:229–236.

Adani G, Filippini T, Michalke B, Vinceti M. Selenium and Other Trace Elements in the Etiology of Parkinson’s Disease: A Systematic Review and Meta-Analysis of Case-Control Studies. Neuroepidemiology 2019;27:1-23.

Sheard JM, Ash S, Silburn PA, Kerr GK. Prevalence of malnutrition in Parkinson’s disease: a systematic review. Nutr Rev 2011;69(9):520–532.

Maraldi T, Riccio M, Zambonin L, Vinceti M, De Pol A, Hakim G. Low levels of selenium compounds are selectively toxic for human neuron cell line through ROS/RNS increase and apoptotic process activation. Neurotoxicology 2011;32:180-187.

Estevez AO, Muller CL, Morgan KL, Szewczyk NJ, Teece L, Miranda-Vizuete A. Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans. Neurotoxicology 2012;33:1021-1032.


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