COMPARATIVE ANALYSIS OF COAGULATION PROFILE IN PREGNANCY INDUCED HYPERTENSIVE WOMEN AND IN NORMOTENSIVE PREGNANT WOMEN IN A TERTIARY CARE HOSPITAL

Abstract

INTRODUCTION: Pregnancy induced hypertension is an elevated blood pressure that appears first time after five months of pregnancy.
Coagulation profile studied in pregnancy induced hypertension is helpful in assessing the severity of coagulation abnormalities at an earlier stage
prior to the occurrence of complications. We studied the changes in Platelet Count, Bleeding Time, Clotting Time, Prothrombin Time and
Activated Partial Thromboplastin Time in pregnancy induced hypertension and in normal pregnant women and compare the above parameters
between the two groups and correlate the above parameters with severity of pregnancy induced hypertension
METHODS AND MATERIALS: Study group consists of 120 pregnant women with 39 weeks in which 60 pregnant women were selected for
control group with normal blood pressure. The remaining 60 pregnant women are with systolic blood pressure of 140 mm of Hg and above and
diastolic blood pressure of 90 mm of Hg and above. Both study groups were matched.
RESULTS: Present study showed the mean Clotting Time for normal pregnancy was 310 seconds, Clotting Time for the non severe PIH was 290
seconds and the severe PIH was 292 seconds and the P-value arrived is 0.269 which is not significant. In the present study the mean Platelet Count
of normal pregnancy, non severe PIH and severe PIH patients were 2.89 lakhs/cubic mm, 2.17lakhs/cubic mm and 1.58 lakhs/cubic mm
respectively with significant P-value of 0.000.In the present study the mean prothrombin time for normal pregnancy, non-severe PIH and severe
PIH patients were 11.05 seconds, 10.19 seconds and 13.06 seconds respectively with significant P-calue of <0.000.In the present study the mean
APTT for normal pregnancy, non severe PIH and severe PIH patients were 29.3 seconds, 29.5 seconds and 32.2 seconds respectively with
significant P-value of <0.007.
CONCLUSION; Bleeding Time, Prothromb in Time and Activated Partial Thromboplastin Time showed prolonged values with severe pregnancy
induced hypertension. With increasing severity of blood pressure in pregnant women significant changes are noted in the coagulation parameters.
Coagulation abnormalities include HELLP Syndrome and Disseminated Intra vascular Coagulation which contribute the causes for maternal
deaths in pregnancy induced hypertension. Present study can be helpful in identifying the coagulation abnormalities in patients with pregnancy
induced hypertension in earlier stage and can be helpful in the management of complications in relation to pregnancy induced hypertension.
Maternal and fetal mortality and morbidity can be reduced with the help of this study.