OUTCOME OF IMMEDIATE POST-OPERATIVE INJECTED PLATELET-RICH PLASMA THERAPY AFTER FOLLICULAR UNIT EXTRACTION HAIR TRANSPLANT: A PROSPECTIVE RANDOMISED STUDY IN FIFTY PATIENTS

Dr Monali Makadia, Dr Meet Poddar

Abstract


Aims and Objectives: The objective of this study was to study efficacy of injectable PRP therapy in follicular unit extraction (FUE) hair transplant.
Method: It is a prospective randomised study on 50 FUE hair transplant subjects, allocated in two groups (PRP and non-PRP) alternately. PRP was
injected immediately post-operatively over the recipient area in PRP group; and normal saline in non-PRP group. Two groups were evaluated at 3, 6
and 9 weeks, 3 and 6 months of the procedure.
Statistical analysis: It was done using Chi-square test and test of significance was set as P < 0.05.
Results: In PRP group, all subjects had >75% hair regrowth at 6 months, density of >75% grafts was noticed in 15 patients at 6 weeks meaning
reduced fall of transplanted hair during catagen phase. New hair growth started at 8 weeks in 12 patients and redness over recipient area completely
disappeared in 20 patients at 3 months of surgery and activity in dormant follicles as fine thread like hair was noticed besides the thick transplanted
hair in all subjects. In non-PRP group, five patients had >75% hair regrowth at 6 months and none showed >75% graft density at 4 weeks.
Conclusion: Intra-operative PRP therapy is beneficial in giving faster density, reducing the catagen loss of transplanted hair, recovering the skin
faster and activating dormant follicles in FUE transplant subjects.


Full Text:

PDF

References


Bienová M, Kucerová R, Fiurásková M, Hajdúch M, Kolár Z. Androgenetic alopecia and current methods of treatment. Acta Dermatovenerol Alp Pannonica Adriat. 2005;14:5–8.

Parsley WM, Perez-Meza D. Review of factors affecting the growth and survival of follicular grafts. J Cutan Aesthet Surg. 2010;3:69–75.

Lacci KM, Dardik A. Platelet-rich plasma: Support for its use in wound healing. Yale J Biol Med. 2010;83:1–9.

Chaudhari ND, Sharma YK, Dash K, Deshmukh P. Role of platelet-rich plasma in the management of androgenetic alopecia. Int J Trichology. 2012;4:291–2.

Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118:1458–66.

Moon PG, Kwack MH, Lee JE, Cho YE, Park JH, Hwang D, et al. Proteomic analysis of balding and non-balding mesenchyme-derived dermal papilla cells from androgenetic alopecia patients using on-line two-dimensional reversed phase-reversed phase LC-MS/MS. J Proteomics. 2013;85:174–91.

Jain R, De-Eknamkul W. Potential targets in the discovery of new hair growth promoters for androgenic alopecia. Expert Opin Ther Targets. 2014;18:787–806.

Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: Clinical and histomorphometric evaluation. Biomed Res Int 2014. 2014 760709.

Bennett NT, Schultz GS. Growth factors and wound healing: Biochemical properties of growth factors and their receptors. Am J Surg. 1993;165:728–37.

Steed DL. The role of growth factors in wound healing. Surg Clin North Am. 1997;77:575.

Perez-Meza D. Wound healing and revascularization of the hair transplant graft: The role of growth factors. Hair Transpl. 1995;1:287.

Rinaldi F, Sorbellini E, Coscera T. The role of platelet rich plasma to control anagen phase: Evaluation in vitro and in vivo hair transplant and hair treatment. Int J Trichology. 2011;3:514–5.

Akiyama M, Smith LT, Holbrook KA. Growth factor and growth factor receptor localization in the hair follicle bulge and associated tissue in human fetus. J Invest Dermatol. 1996;106:391–6.

Arshdeep, Kumaran MS. Platelet-rich plasma in dermatology: Boon or a bane? Indian J Dermatol Venereol Leprol. 2014;80:5–14.

Kamp H, Geilen CC, Sommer C, Blume-Peytavi U. Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle. Exp Dermatol. 2003;12:662–72.

Kang JS, Zheng Z, Choi MJ, Lee SH, Kim DY, Cho SB. The effect of CD34+cell-containing autologous platelet-rich plasma injection on pattern hair loss: A preliminary study. J Eur Acad Dermatol Venereol. 2014;28:72–9.


Refbacks

  • There are currently no refbacks.