A COMPARATIVE STUDY BETWEEN ESMOLOL AND CLONIDINE IN ATTENUATING HYPERDYNAMIC CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN GENERAL ANAESTHESIA AT SHSMSR, GREATER NOIDA

Dr. Manjiri Gupta, Dr. Deepak Mehrotra, Dr. Arti Srivastav, Dr. Debarshi Jana

Abstract


BACKGROUND :Many new studies are still being carried out with re-evaluation of older ones. With this idea an endeavour will be made to
evaluate whether intravenous esmolol or oral clonidine as a premedicant can modify cardiovascular responses to direct laryngoscopy and
endotracheal intubation.
MATERIAL AND METHODS : Present study was carried out in the Department of Anaesthesiology, Sharda Hospital, School of Medical
Sciences and Research, Knowledge Park III, Greater Noida. Sixty patients were chosen for this study. They were of both sexes. Their age ranged
from 18-50 years and weight ranged from 40-75 kg.
RESULTS : In the esmolol group, both the pulse rate and arterial pressure showed a significant rise just after laryngoscopy and intubation. But two
minutes after intubation the rise was statistically insignificant in comparison to control group. Esmolol could check the rise of both pulse rate and
blood pressure at two minutes after intubation.
CONCLUSION : Although increased sedation with clonidine premedication is a undesired side effect but that usually does not require intense
post operative monitoring, as the incidence of respiratory depression following oral clonidine premedication is extremely rare.


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