A PROSPECTIVE OBSERVATIONAL STUDY OF THYROID DYSFUNCTION IN WOMEN WITH ABNORMAL UTERINE BLEEDING HAVING CLINICALLY EUTHYROID STATUS

Dr. Antara Priyadarshini, Dr. Chiranjit Ghosh

Abstract


It is recognized universally that menstrual disturbances may accompany and even may precede thyroid dysfunction.Treating thyroid dysfunction
can reverse menstrual abnormalities and thus improve fertility. A close interplay between thyroid hormones and normal steroid action and secretion
exists, necessary for normal ovarian function and thus fertility. In the present study thyroid status of patients presenting with abnormal uterine
bleeding was assessed by TSH, FT3, and FT4 assay.
MATERIALS AND METHODS : Hospital based study at R G KAR MCH,among the patients attending gynaecology OPD. Various exclusion
and inclusion criteria were used. Analysis was based on intention to treat. Statistical significance in the final calculations was defined as P<0.05.
RESULTS :A total of 260 patients with AUB were included in the present study .In our study 19% women with AUB had thyroid abnormalities.
17.6% were with hypothyroidism, 1.4% with overt hyperthyroidism and 81% were euthyroid.
CONCLUSSION :Thyroid dysfunction should be considered as an important etiological factor for menstrual abnormality. Biochemical
estimation of T3, T4, TSH should be made mandatory in Abnormal uterine bleeding especially in non-structural causes and also in those presenting
with fatigue, obesity, lethargy in addition to infertility ,delayed puberty and recurrent abortions.


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