Dr. Antara Priyadarshini, Dr. Chiranjit Ghosh


It is recognized universally that menstrual disturbances may accompany and even may precede thyroid dysfunction.Treating thyroid dysfunction
can reverse menstrual abnormalities and thus improve fertility. A close interplay between thyroid hormones and normal steroid action and secretion
exists, necessary for normal ovarian function and thus fertility. In the present study thyroid status of patients presenting with abnormal uterine
bleeding was assessed by TSH, FT3, and FT4 assay.
MATERIALS AND METHODS : Hospital based study at R G KAR MCH,among the patients attending gynaecology OPD. Various exclusion
and inclusion criteria were used. Analysis was based on intention to treat. Statistical significance in the final calculations was defined as P<0.05.
RESULTS :A total of 260 patients with AUB were included in the present study .In our study 19% women with AUB had thyroid abnormalities.
17.6% were with hypothyroidism, 1.4% with overt hyperthyroidism and 81% were euthyroid.
CONCLUSSION :Thyroid dysfunction should be considered as an important etiological factor for menstrual abnormality. Biochemical
estimation of T3, T4, TSH should be made mandatory in Abnormal uterine bleeding especially in non-structural causes and also in those presenting
with fatigue, obesity, lethargy in addition to infertility ,delayed puberty and recurrent abortions.

Full Text:



Cunningham F G, Gant N F, Leveno K J et al. William's Obst. 21st Ed. New York, NY: McGraw Hill; 2001:1344.

Neelu Sharma, Anita Sharma. Thyroid Profile in Menstrual Disorders. JK Science. 2012JanuaryMarch;14(1):14-7.

Kaur T, Aseeja V, Sharma S. Thyroid Dysfunction in Dysfunctional Uterine Bleeding.Webmed Central Obstetrics and Gynaecology. 2011;2(9):WMC002235.

Andersen S., Pedersen K.M., Bruun N.H. &Laurberg P. Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease. Journal of Clinical Endocrinology and Metabolism. 2002;87:1068–72.

Baloch Z., Carayon P., Conte-Devolx B., Demers L.M., Feldt-Rasmussen U., Henry J.F., LiVosli V.A., Niccoli-Sire P., John R.,Ruf J., Smyth P.P., Spencer C.A. &Stockigt J.R. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003;13:3–126.

Brabant G., Beck-Peccoz P., Jarzab B., Laurberg P., Orgiazzi J., Szabolcs I., Weetman A.P. &Wiersinga W.M. Is there a need to redefine the upper normal limit of TSH? European Journal of Endocrinology. 2006;154:633–7.

Dr.AchalaSahai Sharma and Dr.Sandhya Gupta .Analysis of body mass index in patients with abnormal uterine bleeding .2019; 3(1): 92-95 .

N Bhavani . A study of correlation between abnormal uterine bleeding and thyroid dysfunction. International Journal of Recent Trends in Science and Technology , 2015; 14(1): 131-135

Verma SK, Pal A, Jaswal S. a study of thyroid dysfunction in dysfunctional uterine bleeding . Int J ReprodContraceptObstetGynecol 2017;6: 2035-9

Int J Appl Basic Med Res. 2012 Jan-Jun; 2(1): 17–19doi: 10.4103/2229-516X.96795

KavithaMarimuthu .MalarvizhiLognathan.International Journal of Reproduction, Contraception, Obstetrics and Gynecology. Int J ReprodContraceptObstet Gynecol. Jun 2017;6(6):2222-2225)


  • There are currently no refbacks.