A PROSPECTIVE STUDY ON THE EFFECTS OF TOPICAL TESTOSTERONE IN MANAGEMENT OF DISTAL HYPOSPADIAS
Abstract
Objectives: The aim was to evaluate the effect of topical testosterone on penile length, preputial hood, vascularity of dartos pedicle in patients with
distal hypospadias.
Materials and Methods: A total of 42 patients patients with distal hypospadias were included in this study. All were randomly allocated to 2
groups before surgical correction. Group 1 did not receive any treatment and group 2 received 1% testosterone propionate ointment twice daily for
30 days before surgery. Increase in penile length, transverse preputial diameter, and diameter at the base of penis were noted.
Results: Following topical testosterone application, the mean increase in penile length, transverse preputial width and diameter at the base of penis
was 1.01 ± 0.25 cm, 1.250 ± 0.52 cm and 0.61 ± 0.35 cm, respectively.
Conclusion: Testosterone increased phallus size, diameter and prepuce hypertrophy without any adverse effects.
Full Text:
PDFReferences
Lambert SM, Snyder HM, Canning DA. The history of hypospadias and hypospadias repairs. Urology 2011;77:1277-83.
Kraft KH, Shukla AR, Canning DA. Hypospadias. Urol Clin North Am 2010;37:167-81
Gearhart JP, Jeffs RD. The use of topical testosterone therapy in genital reconstructive surgery. J Urol 1987;138:1077-8
Gorduza DB, Gay CL, de Mattos E Silva E, Demède D, Hameury F, Berthiller J, et al. Does androgen stimulation prior to hypospadias surgery increase the rate of healing complications? - A preliminary report. J Pediatr Urol 2011;7:158-61.
Kaya C, Bektic J, Radmayr C, Schwentner C, Bartsch G, Oswald J. The efficacy of dihydrotestosterone transdermal gel before primary hypospadias surgery: A prospective, controlled, randomized study. J Urol 2008;179:684-8.
Koff SA, Jayanthi VR. Preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee. J Urol 1999;162:1435-9.
Sakakibara N, Nonomura K, Koyanagi T, Imanaka K. Use of testosterone ointment before hypospadias repair. Urol Int 1991;47:40-3.
Snodgrass WT. Hypospadias. In: Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Campbell-Walsh Urology. 10 th ed. Philadelphia: WB Saunders; 2011. p. 3505.
Chalapathi G, Rao KL, Chowdhary SK, Narasimhan KL, Samujh R, Mahajan JK. Testosterone therapy in microphallic hypospadias: Topical or topical? J Pediatr Surg 2003;38:221-3.
Davits RJ, van den Aker ES, Scholtmeijer RJ, de Muinck Keizer-Schrama SM, Nijman RJ. Effect of topical testosterone therapy on penile development in boys with hypospadias. Br J Urol 1993;71:593-5.
Wiener JS, Sutherland RW, Roth DR, Gonzales ET Jr. Comparison of onlay and tubularized island flaps of inner preputial skin for the repair of proximal hypospadias. J Urol 1997;158:1172-4.
Mustafa M. The concept of tubularized incised plate hypospadias repair for different types of hypospadias. Int Urol Nephrol 2005;37:89-91.
Eliçevik M, Tireli G, Sander S. Tubularized incised plate urethroplasty: 5 years' experience. Eur Urol 2004;46:655-9.
Prat D, Natasha A, Polak A, Koulikov D, Prat O, Zilberman M, et al. Surgical outcome of different types of primary hypospadias repair during three decades in a single center. Urology 2012;79:1350-3.
Nerli RB, Koura A, Prabha V, Reddy M. Comparison of topical versus topical testosterone in children with microphallic hypospadias. Pediatr Surg Int 2009;25:57-9.
Bastos AN, Oliveira LR, Ferrarez CE, de Figueiredo AA, Favorito LA, Bastos Netto JM. Structural study of prepuce in hypospadias - does topical treatment with testosterone produce alterations in prepuce vascularization? J Urol 2011;185:2474-8.
Netto JM, Ferrarez CE, Schindler Leal AA, Tucci S Jr, Gomes CA, Barroso U Jr. Hormone therapy in hypospadias surgery: A systematic review. J Pediatr Urol 2013;9:971-9.
Refbacks
- There are currently no refbacks.