ROLE OF KI67 AS A PROLIFERATIVE MARKER IN LESIONS OF THYROID

Dr. Prajakta patil, Dr. Vijay. Mulay, Dr. Anuprita Kulkarni, Dr. Anil Joshi

Abstract


INTRODUCTION :This study was conducted to assess utility of Ki67 as  proliferation marker in thyroid lesions and for usefulness of Ki-67 in distinguishing benign and malignant thyroid lesions. MATERIALS AND METHODS In present study 50 cases of non- and neoplastic thyroid lesions were included. Histopathological diagnosis achieved on gross and microscopy of h&e stained slides followed by Ki-67. RESULTS  In present study Ki67 labeling index were counted. Range of Ki67 LI for multinodular goiter is 0.1 to 0.9 and mean 0.29. For Hashimoto thyroiditis range was 0.3 to 0.6 & mean 0.42. In follicular adenoma range was 0.6 to 1.4 and mean 0.9. Range of Ki67 LI for Papillary carcinoma was 2.6 to 4.9 and mean 3.7. For Follicular carcinoma range was 4.6 to 9.1 & mean 6.6.  Ki67 LI was much higher in Anaplastic carcinoma i.e 35. CONCLUSION There was statistically significant difference in benign and malignant thyroid lesions.

 

 


Full Text:

PDF

References


Chaudhury M, Singh S, Agarwal S. Diagnostic utility of Ki67 and p53 immunostaining on solitary thyroid nodule--a cytohistological and radionuclide scintigraphic study. Indian J Pathol Microbiol. 2011;54(3):472–5.

Miyauchi A, Kudo T, Hirokawa M, Ito Y, Kihara M, Higashiyama T, et al. Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma. Eur Thyroid J. 2013;2(1):57–64.

Ranjbari N, Rahim F. The Ki-67/MIB-1 index level and recurrence of papillary thyroid carcinoma. Med hypothesis. 2013;80(3):311–4.

Kumar V, Abbas AK AJ. Robbins and Cotran Pathologic Basis of Disease. 9th ed. 2014. 1092 p.

Bashandy MA, Aiad HA, Abdou AG, Zahran AA. Dignostic application of AgNORs Quntification and Ki-67 In Different Thyroid Lesions. Kasr El Ainy Medical Journal 2012;18(2):73-84.

Pujani M, Arora B, Singh SK TN. Role of Ki-67 as a proliferative marker in lesions of thyroid. Indian J Cancer. 2011;47(3):304–7.

Ludvikova M, Holubec Jr. L, Ryska A, Topolcan O. Proliferative markers in diagnosis of thyroid tumors: a comparative study of MIB-1 and topoisomerase II-a immunostaining. Anticancer Res. 2005;25:1835–40.

Ntzeros K, Stanier P, Mazis D, Kritikos N et al. MKI67 (marker of proliferation Ki-67). Atlas Genet Cytogenet Oncol Haematol. 2014

Shuja A. History of thyroid surgery. Prof Med J. 2008;15(2):295–7.

Esmaili HA, Taghipour H. Fine-Needle Aspiration in the Diagnosis of Thyroid Diseases: An Appraisal in Our Institution. ISRN Pathol. 2012;2012(September 2011):1–4.


Refbacks

  • There are currently no refbacks.