BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF NON-FERMENTING GRAM-NEGATIVE BACTERIAL BLOOD STREAM INFECTIONS

Shagila R, Sapthagiri B, Blessy Rejoice P, Ishwarya P, Sandhya Bhat K

Abstract


Introduction: Non‑fermenting Gram‑negative bacilli (NFGNB) have emerged as a major nosocomial pathogens and many of them are intrinsically resistant to multiple antibiotics. This study was undertaken to determine the prevalence and susceptibility pattern of nonfermenters isolated from blood samples in patients with clinically suspected blood stream infections. Methods: All 102 blood isolates of NFGNBs were identified by conventional bacteriological methods and susceptibility testing was performed as per Clinical Laboratory Standard Institute (CLSI) standards. Results: Overall prevalence of NFGNBs isolation from blood specimen was 12.2%. P. aeruginosa and Acinetobacter species were the commonest isolates (73.5%). P. aeruginosa isolates were highly susceptible to imipenem (93%), meropenem (89.7%), and ceftazidime (82.8%), gentamicin (86.2%) and Acinetobacter spp. showed high rate of resistance to most of the tested antimicrobial agents. Intrinsically resistance to polymyxin B was seen among Burkholderia pseudomallei (8.8%) and B.cepacia (4.9%) isolates. Conclusion: Accurate species identification and close monitoring of antimicrobial susceptibility patterns of NFGNBs is the corner stone for the proper management of the infections caused by them.


Keywords


Nonfermentative gram-negative bacilli (NFGNB), prevalence, Acinetobacter baumannii, Pseudomonas aeruginosa, multidrug resistant

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References


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