NEUTROPHIL TO LYMPHOCYTE RATIO PREDICTS SURVIVAL IN PRIMARY CNS LYMPHOMA : CASE SERIES FROM A TERTIARY CARE CENTRE

Arun Philip, Wesley Jose, Beena K, Pavithran K

Abstract


INTRODUCTION
Primary Central nervous system Lymphoma (PCNSL) is a form of
extra nodal Non Hodgkin lymphoma (NHL) which is restricted to the
brain, spine, eyes and cerebrospinal fluid (CSF). Compared to NHL
outside the CNS, the prognosis of PCNSL is poor.1 It is a very rare
tumor, accounting for less than 4% of all intracranial tumors and about
5% of all extranodal NHL.2 Published data from the Indian population
is limited. Prognosis of untreated patients is extremely poor. We
wanted to analyze the prognostic factors associated with PCNSL in our
patients. A handful of prognostic scores have been validated in
PCNSL; age and performance status being the two consistent
parameters in this regard.3,4 The value of other prognostic markers have
been inconsistent across studies. Hence, a special focus of the study
was on the value of Neutrophil Lymphocyte ratio (NLR) as a
prognostic marker in our PCNSL patients. The NLR is a simple tool
which is being explored in relation to many malignancies as a
prognostic marker and have been proven to be useful in many
malignancies including breast, gastric and lung cancers.5-7


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References


Christian Grommes, Lisa M. DeAngelis: Primary CNS Lymphoma. J Clin Oncol 35:2410-2418.

Villano JL, Koshy M, Shaikh H, et al: Age, gender, and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer 105: 1414-1418, 2011

Ferreri AJ, Blay JY, Reni M, et al: Prognostic scoring system for primary CNS lymphomas: The International Extranodal Lymphoma Study Group experience. J Clin Oncol 21:266-272, 2003

Abrey LE, Ben-Porat L, Panageas KS, et al: Primary central nervous system lymphoma: The Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol 24:5711-5715, 2006

Hany Noh, Minseob Eomm, and Airi Han. Usefulness of Pretreatment Neutrophil to Lymphocyte Ratio in Predicting Disease-Specific Survival in Breast Cancer. J Breast cancer 2013 March, 16.1: 55-59

Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007;73:215–220.

Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 2009;137:425–428

Nelson DF, Martz KL, Bonner H, et al: Non-Hodgkin’s lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 23:9-17, 1992

Shibamoto Y, Ogino H, Hasegawa M, et al: Results of radiation monotherapy for primary central nervous system lymphoma in the 1990s. Int J Radiat Oncol Biol Phys 62:809-813, 2005

DeAngelis LM, Yahalom J, Thaler HT, et al: Combined modality therapy for primary CNS lymphoma. J Clin Oncol 10:635-643, 1992

Glass J, Gruber ML, Cher L, et al: Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: Long-term outcome. J Neurosurg 81:188-195, 1994


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