Arun Philip, Wesley Jose, Beena K, Pavithran K


Primary Central nervous system Lymphoma (PCNSL) is a form of
extra nodal Non Hodgkin lymphoma (NHL) which is restricted to the
brain, spine, eyes and cerebrospinal fluid (CSF). Compared to NHL
outside the CNS, the prognosis of PCNSL is poor.1 It is a very rare
tumor, accounting for less than 4% of all intracranial tumors and about
5% of all extranodal NHL.2 Published data from the Indian population
is limited. Prognosis of untreated patients is extremely poor. We
wanted to analyze the prognostic factors associated with PCNSL in our
patients. A handful of prognostic scores have been validated in
PCNSL; age and performance status being the two consistent
parameters in this regard.3,4 The value of other prognostic markers have
been inconsistent across studies. Hence, a special focus of the study
was on the value of Neutrophil Lymphocyte ratio (NLR) as a
prognostic marker in our PCNSL patients. The NLR is a simple tool
which is being explored in relation to many malignancies as a
prognostic marker and have been proven to be useful in many
malignancies including breast, gastric and lung cancers.5-7

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