AGE-BASED INTERPRETATION OF ANTI-MULLERIAN HORMONE (AMH) LEVELS IN FERTILE AND INFERTILE WOMEN

Sahana K. R, Pranathi M, Geetha H, Ravikumar H. N

Abstract


INTRODUCTION: Data related to AMH levels in fertile women are scarce, making interpretation for this population difficult. We aimed to characterize age-based AMH levels both in fertile and infertile women population to simplify interpretation of AMH results. This study represents the largest analysis to date of AMH levels in fertile women.

Materials and Methods: This cross-sectional study analyzed serum AMH  from 543 infertile women and 492 healthy controls, whose mean ages were 20-50 years. Sample collection was performed by random sampling and analyzed with SPSS version 16 software. AMH levels were abstracted from electronic medical records. AMH levels were measure by an independent laboratory RV Metro Polis by Chemiluminescence method.

Results: There were significantly lower mean serum AMH levels among infertile women compared to the control group. The mean AMH serum levels from different ages of infertile and control group (fertile women) decreased with increasing age.

Conclusion: We have observed decreased AMH levels with increasing age both in fertile and infertile women from 20 to 50 years of age. Assessments of AMH levels indifferent age group of female  can help in predicting ovarian reserve in infertile women.

 


Keywords


Anti-Müllerian Hormone, Infertile, Fertile , Age .

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References


de Vet A, Laven JS, de Jong FH, Themmen AP, Fauser BC. 2002. Antimüllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril 77:357–362 [PubMed] [Google Scholar]

Gruijters MJ, Visser JA, Durlinger AL, Themmen AP. 2003. Anti-Müllerian hormone and its role in ovarian function. Mol Cell Endocrinol 211:85–90 [PubMed] [Google Scholar]

Feyereisen E, Méndez Lozano DH, Taieb J, Hesters L, Frydman R, Fanchin R. 2006. Anti-Müllerian hormone: clinical insights into a promising biomarker of ovarian follicular status. Reprod Biomed Online 12:695–703 [PubMed] [Google Scholar]

Scheffer GJ, Broekmans FJ, Looman CW, Blankenstein M, Fauser BC, teJong FH, teVelde ER. 2003. The number of antral follicles in normal women with proven fertility is the best reflection of reproductive age. Hum Reprod 18:700–706 [PubMed] [Google Scholar]

van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, Themmen AP. 2002. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 17:3065–3071 [PubMed] [Google Scholar]

Yang YS, Hur MH, Kim SY, Young K. 2011. Correlation between sonographic and endocrine markers of ovarian aging as predictors for late menopausal transition. Menopause 18:138–145 [PubMed] [Google Scholar]

Hansen KR, Hodnett GM, Knowlton N, Craig LB. 2011. Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril 95:170–175 [PubMed] [Google Scholar]

La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS; ESHRE Special Interest Group for Reproductive Endocrinology–AMH Round Table 2009. Anti-Mullerian hormone (AMH): what do we still need to know? Hum Reprod 24:2264–2275 [PubMed] [Google Scholar]

van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, Fauser BJ, Themmen AP, te Velde ER. 2005. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril 83:979–987 [PubMed] [Google Scholar]

van Disseldorp J, Faddy MJ, Themmen AP, de Jong FH, Peeters PH, van der Schouw YT, Broekmans FJ. 2008. Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab 93:2129–2134 [PubMed] [Google Scholar]

Schnatz PF, Jiang X. 2011. Predicting age of menopause: what is the future of the antimüllerian hormone biomarker? Menopause 18:727–729 [PubMed] [Google Scholar]

Tehrani FR, Shakeri N, Solaymani-Dodaran M, Azizi F. 2011. Predicting age at menopause from serum antimüllerian hormone concentration. Menopause 18:766–770 [PubMed] [Google Scholar]

Broer SL, Eijkemans MJ, Scheffer GJ, van Rooij IA, de Vet A, Themmen AP, Laven JS, de Jong FH, Te Velde ER, Fauser BC, Broekmans FJ. 2011. Anti-mullerian hormone predicts menopause: a long-term follow-up study in normoovulatory women. J Clin Endocrinol Metab 96:2532–2539 [PubMedGoogle Scholar]

Plante BJ, Cooper GS, Baird DD, Steiner AZ. 2010. The impact of smoking on antimüllerian hormone levels in women aged 38 to 50 years. Menopause 17:571–576 [PMC free article] [PubMed] [Google Scholar]

Steiner AZ, Stanczyk FZ, Patel S, Edelman A. 2010. Antimullerian hormone and obesity: insights in oral contraceptive users. Contraception 81:245–248 [PMC free article] [PubMed] [Google Scholar

Seifer DB, Baker VL, Leader B. Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril.

; 95(2): 747-750.

Alireza Raeissi, M.Sc.1, Alireza Torki, M.Sc.1, Ali Moradi, Ph.D.1*, Seyed Mehdi Mousavipoor,

M.Sc.2, Masoud Doosti Pirani, M.Sc. Age-Specific Serum Anti-Mullerian Hormone and Follicle Stimulating Hormone Concentrations inInfertile Iranian Women, Int J Fertil Steril, Vol 9, No 1, Apr-Jun 2015;32.

Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum mullerian-inhibiting substance levels are associated with ovarian response during assisted

reproductive technology cycles. Fertil Steril. 2002;77(3) : 468-471.

Maslow, Bat-Sheva L. MD, MSCTR; Guarnaccia, Michael MPH, MD; Hennessy, Dayna MSN, NP-C; Klein, Joshua U. MD; Age-Based Interpretation of Anti-Mullerian Hormone (AMH) Levels in Non-infertile Women [37J]Obstetrics & Gynecology: May 2019 - Volume 133 - Issue - p 117S-118S


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