CORRELATION BETWEEN SERUM FERRITIN WITH COMPONENTS OF METABOLIC SYNDROME

Dr. Sadhna Sharma, Dr. D. Shiv Sankar, Dr. V. Aravind Kumar

Abstract


Background: Metabolic syndrome is described by WHO as a pathological disorder characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. It is hypothesized that elevated serum ferritin levels, in the absence of high transferrin saturation, have appeared during the last years as a common characteristic in some patients with metabolic syndrome.

Objectives:

  1. To identify the correlation between serum ferritin and components of metabolic syndrome.

Methodology: A cross-sectional study was carried out in 102 patients diagnosed with metabolic syndrome as per NCEP (National Cholesterol Education Program) ATP III (Adult Treatment Panel III) (2001) attending the NRI medical college and Hospital during the study period, and their serum ferritin levels were studied to find any significant association exists.

Results: In the present study, the mean age group of the study population was 57.38 ± 8.05. Gender distribution shows male 62.7% and female were 37.3. Study showed  a significant correlation between serum ferritin and waist circumference (r=0.33, p-value <0.05), Total Cholesterol (r=0.310;p-value<0.0001), and LDL (r = 0.326; p value <0.0001).

Conclusion: A significant correlation was observed between serum ferritin and waist circumference (r=0.33, pvalue <0.05), Total Cholesterol(r=0.310, pvalue<0.0001), and LDL(r = 0.326; p value <0.0001).


Keywords


WHO, pathological disorder, Metabolic syndrome, NCEP (National Cholesterol Education Program)

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References


Swarup S, Zeltser R. Metabolic Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 [cited 2019 Nov 24]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK459248/

Saklayen MG. The Global Epidemic of Metabolic Syndrome. Curr Hypertens Rep [Internet]. 2018 [cited 2019 Nov 24];20(2). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866840/

National Center for Chronic Disease Prevention and Health Promotion, CDC. National Diabetes Statistics Report, 2017. National Center for Health Statistics, Division of Health Interview Statistics. 2017;20.

Park SK, Ryoo J-H, Kim M-G, Shin J-Y. Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study. Diabetes Care. 2012 Dec;35(12):2521–6.

Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004 Oct;27(10):2422–8.

Brudevold R, Hole T, Hammerstrøm J. Hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload. PloS One. 2008;3(10):e3547.

Kumar DA. Study of Serum Ferritin Level and its Correlation with Metabolic Syndrome. J Med Sci Clin Res [Internet]. 2019 Jul 8 [cited 2019 Nov 25];7(7). Available from: http://jmscr.igmpublication.org/v7-i7/35%20jmscr.pdf

Sudhakar B, Rita M S. Correlation of Serum Ferritin with Components of Metabolic Syndrome and its Relationship with the Insulin Resistance in Men in Women. Clin Med Biochem Open Access [Internet]. 2016 [cited 2019 Nov 25];02(01). Available from: https://www.omicsonline.org/open-access/correlation-of-serum-ferritin-with-components-of-metabolic-synd-romeand-its-relationship-with-the-insulin-resistance-in-men-in-wom-cmbo-1000109.php?aid=67308

Bongale S, G Y, T N. STUDY OF SERUM FERRITIN IN METABOLIC SYNDROME AND ITS COMPONENTS. J Evid Based Med Healthc. 2015 Aug 6;2:4743–53.

Preeti S. ASSESSMENT OF METABOLIC SYNDROME: ROLE OF SERUM FERRITIN. Asian J Pharm Clin Res. 2016;9(4):240–3.

Prasad DS, Kabir Z, Dash AK, Das BC. Prevalence and risk factors for metabolic syndrome in Asian Indians: A community study from urban Eastern India. J Cardiovasc Dis Res. 2012;3(3):204–11.

Harikrishnan S, Sarma S, Sanjay G, Jeemon P, Krishnan MN, Venugopal K, et al. Prevalence of metabolic syndrome and its risk factors in Kerala, South India: Analysis of a community based cross-sectional study. PLoS ONE [Internet]. 2018 Mar 27 [cited 2019 Nov 25];13(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870937/

Sawant A, Mankeshwar R, Shah S, Raghavan R, Dhongde G, Raje H, et al. Prevalence of Metabolic Syndrome in Urban India [Internet]. Cholesterol. 2011 [cited 2019 Nov 25]. Available from: https://www.hindawi.com/journals/cholesterol/2011/920983/

Cohen E, Margalit I, Goldberg E, Krause I. Gender as an Independent Risk Factor for the Components of Metabolic Syndrome Among Individuals Within the Normal Range of Body Mass Index. Metab Syndr Relat Disord. 2018 Sep 11;16(10):537–42.

Tian X, Xu X, Zhang K, Wang H. Gender difference of metabolic syndrome and its association with dietary diversity at different ages. Oncotarget. 2017 Sep 2;8(43):73568–78.

Maiti S, Kumar A. Does serum Ferritin determines additional risk in metabolic syndrome? – A pilot study to focus on the missing links. 2016;2(1):8.

Sivasankari J, Thiruchelvan V. Serum Ferritin: An Early Marker of Insulin Resistance in Metabolic Syndrome. 2017;5(2):6.

Ramesh G, Sai NVB, Gururaj P, Bhupal R, Patel N. Association of metabolic syndrome and level of hs-CRP, Lp(a), and serum ferritin in young Asian patients (≤45 years) with acute myocardial infarction. Interv Med Appl Sci. 2018 Jun 1;10(2):65–9.

Sharma G, Bansal S. A Study of Serum Ferritin Activity in Metabolic Syndrome. 2013;5(4):3.


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