SERUM AMYLASE LEVELS IN PATIENTS OF END STAGE RENAL DISEASEA PROGNOSTIC FACTOR

Pranav Mehta, Mowar A B, Grover Ankit, Johri Sharat

Abstract


BACKGROUND- Chronic Kidney Disease(CKD) encompasses a spectrum of path physiologic process associated with abnormal kidney function and a progressive decline in glomerular filtration rate(GFR).  Amylase enzyme is rapidly excreted by kidney so there is elevated serum Amylase in patients of CKD.

AIM- To study correlation between serum amylase and Urea, Creatinine levels by measuring the level of serum Amylase in patients with CKD- ESRD and in healthy controls.

MATERIAL AND METHOD-50 Non dialysed chronic kidney disease patients and 50 patients with End stage Renal Disease on hemodialysis coming to  Medicine and nephrology department  at Shri Ram Murti Smarak Institute Of Medical Sciences and Hospital, during time period of May 2018-June2019 were included in this study.Quantitative analysis of Serum Amylase, Urea and Creatinine were done by photometric method.

RESULTS-Our study showed Serum Amylase levels were significantly higher in end stage renal disease and chronic kidney disease patients as compared to healthy controls(p value<0.05)

CONCLUSION-Use of Serum Amylase as a diagnostic tool in recognising Acute Pancreatitis in CKD patients can lead to false positive results.


Keywords


Chronic Kidney Disease(CKD), glomerular ltration rate(GFR), hemodialysis

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References


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