AMINOTRANSFERASES AND TOTAL SERUM BILIRUBIN LEVEL DERANGEMENT IN PATIENTS WITH DENGUE INFECTION

Gupta R, Tomar R, Kumar M, Verma S, Dubey M

Abstract


Background: Dengue infection can affect the liver with a wide spectrum of manifestations. The aim of this study was to evaluate the impact of dengue virus infection on liver function by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total serum bilirubin levels in patients serologically diagnosed with NS1 ELISA.

Methods: NS1 ELISA positive patients were included in the study and all the patients underwent aminotransferase and bilirubin analysed.

Results: AST was elevated more as compared to ALT and hyperbilirubinemia was observed in 9.2% of cases.

Conclusion: Transaminase level analysis in dengue patients are crucial markers for severe acute liver cell injury.


Keywords


ALT, AST, Dengue Fever, Hyperbilirubinemia

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References


Ukey PM, Bondade SA, Paunipagar PV, Power RM, Akulwar SL. Study of seroprevalence of dengue fever in central india. Indian J Community Med. 2010; 35(4):517-9.

World Health Organisation: Dengue haemorrhagic fever: Diagnosis, Treatment, Prevention and Control. 2nd ed, Geneva: World Health Organisation. 1997:12-23.

Seshan V, Sarangan G, Sheriff K, Krishnasamy K, Palani G, Srikanth P. Serological, molecular and clinical correlates of dengue from a tertiary care centre in Chennai, India Archives of Virology 2017. Jun 16.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue Nature 2013. Apr; 496 (7446):504 - 7.

Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, Moyes CL, Farlow AW, Scott TW, Hay SI. Refining the global spatial limits of dengue virus transmission by evidence-based consensus PLoS Neglected Tropical Disease 2012. ;6 (8):e1760.

Shepard DS, Undurraga EA, Betancourt-Cravioto M, Guzmán MG, Halstead SB, Harris E, Mudin RN, Murray KO, Tapia-Conyer R, Gubler DJ. Approaches to refining estimates of global burden and economics of dengue PLoS Neglected Tropical Disease 2014. Nov; 8 (11):e3306.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue. Nature;496:504-507.

Itha S, Kashyap R, Krishnani N, Saraswat VA, Choudhuri G, Aggarwal R. Profile of liver involvement in dengue virus infection. Natl Med J India 2005;18:127-30.

Martina BE, Koraka P, Osterhaus AD. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 2009; 22: 564-581 [PMID:19822889 DOI: 10.1128/CMR.00035-09].

Marianneau P, Steffan AM, Royer C, Drouet MT, Jaeck D, Kirn A, Deubel V. Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident. J Virol 1999; 73: 5201-5206 [PMID: 10233989].

Thongtan T, Panyim S, Smith DR. Apoptosis in dengue virus infected liver cell lines HepG2 and Hep3B. J Med Virol 2004; 72: 436-444 [PMID: 14748067 DOI:10.1002/jmv.20004].

Seneviratne SL, Malavige GN, de Silva HJ. Pathogenesis of liver involvement during dengue viral infections. Trans R Soc Trop Med Hyg 2006; 100: 608-614 [PMID: 16483623 DOI: 10.1016/ j.trstmh.2005.10.007].

Huerre MR, Lan NT, Marianneau P, Hue NB, Khun H, Hung NT, Khen NT, Drouet MT, Huong VT, Ha DQ, Buisson Y, Deubel V. Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 2001; 438: 107-115 [PMID: 11253111].

Parkash O, Almas A, Jafri SM, Hamid S, Akhtar J, et al. (2010) Severity of acute hepatitis and its outcome in patients with dengue fever in a tertiary care hospital Karachi, Pakistan (South Asia). BMC Gastroenterol 10: 43.

Souza LJ, Alves JG, Nogueira RM, Gicovate Neto C, Bastos DA, et al. (2004) Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases. Braz J Infect Dis 8: 156–163.

Trung DT, Thao le TT, Hien TT, Hung NT, Vinh NN, et al. (2010) Liver involvement associated with dengue infection in adults in Vietnam. Am J Trop Med Hyg 83: 774–780.

Wilder-Smith A, Earnest A, Paton NI (2004) Use of simple laboratory features to distinguish the early stage of severe acute respiratory syndrome from dengue fever. Clin Infect Dis 39: 1818–1823.

Avirutnan P, Zhang L, Punyadee N, Manuyakorn A, Puttikhunt C, et al. (2007) Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog 3: e183.

Alcon-LePoder S, Drouet MT, Roux P, Frenkiel MP, Arborio M, et al. (2005) The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity. J Virol 79: 11403-11411.

Narasimhan D, Ponnusamy P, M. Sathish. Analysis of liver function tests in dengue fever. Int J Adv Med 2018;5:47-9.

Larreal Y, Valero N, Estevez J, Reyes I, Maldonado M, Espina LM, et al. Hepatic alterations in patients with dengue. Invest Clin. 2005;46(2):169-78.

Soni A, Patel PM, Malhi NS, Avasthi GL. Spectrum of Liver Dysfunction in Patients with Dengue Infection and the Markers of Severe Disease: Study from a Tertiary Care Centre in Punjab. J Liver Res Disord Ther. 2017;3(4):00063.

Samanta J, Sharma V. Dengue and its effects on liver. W J Clinic Cases: WJCC. 2015;3(2):125.


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