ANALYSIS OF PREDICTIVE FACTORS OF AXILLARY LYMPH NODE METASTASIS IN BREAST CANCER PATIENTS

Hemalatha G, Sudha V

Abstract


Aim: To evaluate the predictive factors for axillary lymph node metastasis in breast cancer patients. Materials and methods:  Patients diagnosed with invasive breast carcinoma and underwent modified radical mastectomy  were included in the study. Parameters like histological grade, ER, PR and HER2 status were analyzed. Results: 25% of grade 1 cases showed positive nodal metastasis. Grade 2 and 3 tumors showed 36% and 50% nodal positivity respectively. 48% of ER positive tumors showed nodal metastasis whereas 50% of ER negative cases had positive nodes. Out of the 25 cases that showed PR positivity, nodal metastasis was seen in 52% of cases. Positive lymph node metastasis was seen in 76% of cases with HER2 positivity and only 37% of cases with HER2 negativity. Conclusion : Higher grade and HER2 positivity were associated with increased lymph node metastasis.


Keywords


Axillary lymph node metastasis, histological grade, ER, PR and HER2 status

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References


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