ADMISSION HYPERGLYCEMIA AS A PROGNOSTIC MARKER FOR ACUTE ST ELEVATION MYOCARDIAL INFARCTION.
Abstract
BACKGROUND: Hyperglycemia is common in patients admitted with acute myocardial infarction and it is associated
with increased mortality and morbidity. Patients either with or without prior history of diabetes mellitus may present with
hyperglycemia during acute myocardial infarction an it is uncertain whether hyperglycemia upon admission remains an independent predictor of
in hospital morbidity and mortality. This study was aimed to assess the impact of admission blood glucose levels on the hospital course and
outcome in diabetic and non-diabetic patients admitted with acute myocardial infarction.
METHODS: 50 patients with acute myocardial infarction were divided into two groups based on their prior diagnosis of diabetes mellitus. Each
group was further divided into two groups with admission blood glucose levels less than 180 mg/dl and greater than 180mg/dl. All patients were
subjected to complete history taking and clinical examination, ECG, routine laboratory investigation including cardiac enzymes, admission
blood glucose level, HbA1c.
RESULTS: In this study of 50 patients, 25 were diabetic and 25 non diabetic. 22 had blood glucose levels less than 180 mg/dl and 28 had greater
than 180mg/dl. Patients who had arrhythmia were 10, of which 2 had blood glucose level less than 180mg/dl and 8 had blood glucose more than
180mg/dl. 7 had heart failure of which 3 had blood glucose less than 180mg/dl and 4 had greater than 180mg/dl. Total 3 deaths had occurred and
all had blood glucose greater than 180mg/dl.
CONCLUSIONS: Admission hyperglycemia was associated with increased complication in both diabetic and non-diabetic patients with acute
myocardial infarction.
Full Text:
PDFReferences
Wahab, N. N., Cowden, E. A., Pearce, N. J., Gardner, M. J., Merry, H., Cox, J. L., & ICONS investigators. (2002). Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?. Journal of the American College of Cardiology, 40(10), 1748-1754.
.Monteiro, S., Monteiro, P., Gonçalves, F., Freitas, M., & A. Providěncia, L. (2010). Hyperglycaemia at admission in acute coronary syndrome patients: prognostic value in diabetics and non-diabetics. European Journal of Cardiovascular Prevention & Rehabilitation, 17(2), 155-159.
Angeli, F., Reboldi, G., Poltronieri, C., Lazzari, L., Sordi, M., Garofoli, M., ... & Verdecchia, P. (2015). Hyperglycemia in acute coronary syndromes: from mechanisms to prognostic implications. Therapeutic advances in cardiovascular disease, 9(6), 412-424.
Chakrabarti, A. K., Singh, P., Gopalakrishnan, L., Kumar, V., Elizabeth Doherty, M., Abueg, C., ... & Gibson, C. M. (2012). Admission hyperglycemia and acute myocardial infarction: outcomes and potential therapies for diabetics and nondiabetics. Cardiology research and practice, 2012.
Buja, L. M. (2005). Myocardial ischemia and reperfusion injury. Cardiovascular pathology, 14(4), 170-175.
Umpierrez, G. E., Isaacs, S. D., Bazargan, N., You, X., Thaler, L. M., & Kitabchi, A. E. (2002). Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. The Journal of Clinical Endocrinology & Metabolism, 87(3), 978-982.
Finney, S. J., Zekveld, C., Elia, A., & Evans, T. W. (2003). Glucose control and mortality in critically ill patients. Jama, 290(15), 2041-2047.
Bartnik, M., Rydén, L., Ferrari, R., Malmberg, K., Pyörälä, K., Simoons, M., ... & Öhrvik, J. (2004). The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe: The Euro Heart Survey on diabetes and the heart. European heart journal, 25(21), 1880-1890.
Kosiborod, M. (2008). Blood glucose and its prognostic implications in patients hospitalised with acute myocardial infarction. Diabetes and Vascular Disease Research, 5(4), 269-275.
Eitel, I., Hintze, S., Waha, S. D., Fuernau, G., Lurz, P., Desch, S., ... & Thiele, H. (2012). Prognostic impact of hyperglycemia in nondiabetic and diabetic patients with ST-elevation myocardial infarction: insights from contrast-enhanced magnetic resonance imaging. Circulation: Cardiovascular Imaging, 5(6), 708-718.
Senthinathan, A., Kelly, V., Dzingina, M., Jones, D., Baker, M., & Longson, D. (2011). Hyperglycaemia in acute coronary syndromes: summary of NICE guidance. BMJ, 343, d6646.
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000). Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. The Lancet, 355(9206), 773-778.
Refbacks
- There are currently no refbacks.