COMPARATIVE NEPHROPROTECTIVE EFFECT OF CINNAMOMUM CASSIA AND ZINGIBER OFFICINAL ON DIABETIC RAT

Asif Iqubal, Arun Kumar Singh, Sunil Kumar Singh, Md Ali, Arun Kumar, Ranjit Kumar

Abstract


Diabetes is exponentially growing disease in developed and developing country in last few decades. Diabetes mellitus is
a metabolic disorder characterized by chronic hyperglycaemia. Alloxan were introduced intra-peritoneally @ 125
mg/kg/b.w to prepare diabetic model. Diabetic control group rat were treated with distilled water while diabetic rat were treated with
Cinnamomum cassia @ 50 mg/kg/b.w and Zingiber officinale @ 200 mg/kg/b.w separately for 8 weeks. Glucose level was increased many folds in
diabetic rat. Urea, uric acid, creatinine and LPO were increased in diabetic group of rat. Cinnamon and ginger restores urea, uric acid, creatinine
and LPO effectively after 8 weeks of administration. It is concluded from entire study that cinnamon and ginger both acts very effectively against
diabetes on biochemical parameters of rat. Both restore glucose level to normal level. Cinnamon effectively restores KFT and LPO very well in
comparison to ginger administered group. It was evident from study that cinnamon causes more effective restoration in biochemical parameters of
rat.


Keywords


Lpo, Metabolic Disorders, Hyperglycemia,alloxan

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