A RARE CASE OF VALPROATE INDUCED HEPATO-TOXICITY

Dr. V. C. Singel, Dr. Kartikeya Parmar, Dr. Vijay Dhalavaniya, Dr. Khanjan Patel, Dr. Swansu Batra

Abstract


Drug Induced Liver Injury(DILI) can occur owing to a dose dependent or idiosyncratic reaction to a drug. Valproate induced hepato-toxicity can lead to Acute hepatic failure, occasionally can progress to fulminant hepatic failure and may require liver transplantation.

Valproate being a commonly used drug, most physicians need to exert a cautious approach for judicious use of the drug. Hereby, we aim to discuss different manifestations of Valproate induced Hepato-toxicity and it’s medical management.


Keywords


Valproate hepato-toxicity, hyperammonemia, L-carnitine, Reye like syndrome, Hy’s law.

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References


Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012 .LiverTox: Clinical and Research Information on Drug-Induced Liver Injury https://www.ncbi.nlm.nih.gov/books/NBK548284/

Zimmerman HJ, Ishak KG. Valproate‐induced hepatic

injury: analysis of 23 fatal cases. Hepatology 1982; 2: 592-597

Sherlock’s Diseases Of The Liver And Biliary System Chapter 24: Drug Induced Liver Injury

University Of Maryland School Of Pharmacy; July 2012


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