VITAMIN D DEFICIENCY AND ITS EFFECT ON SEVERITY OF ASTHMA IN ADULT
Abstract
AIM: This study aimed to assess vitamin D status in asthmatic patients and to assess the relationship
between vitamin D level and asthma severity.
INTRODUCTION: Asthma is heterogeneous disease, usually characterized by variable airow obstruction and bronchial
hyper-responsiveness. The world health organization stated that approximately 300 million people have asthma. Recently the
effects of vitamin D appear to have regulatory effect on every part of immune system, vitamin D deciency being linked to an
array of immunologically based disease focusing on asthma.
METHOD: The present study included 50 patients diagnosed as bronchial asthma. The asthmatic patient group was divided
into group A asthma in between attack and group B exacerbated asthma, that was again divided in subgroup (I), (II), and (III)
mild , moderate and severe exacerbated asthma according to symptoms and FEV1. Serum 25 hydroxy vitamin D level in all 3
groups was measured by radio immunoassay method and compared between this groups.
RESULT : This study shows statistically signicant correlation between vitamin D level and severity of asthma. The mean levels
of serum 25 hydroxy vitamin D in asthmatic patients are: Group A 28.24 ± 1.35 ng/ml, mild persistent: 22.6 ± 11.5 ng/ml, 3
moderate persistent: 18.33 ± 1.31 ng/ml, and severe persistent: 10.45 ± 1.84 ng/ml. P value of <0.01 which is highly signicant.
CONCLUSION : There was a correlation between asthma severity and vitamin D level. Further studies are needed to determine
the role of vitamin D in treatment of bronchial asthma.
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