HISTOPATHOLOGICAL AND BIOCHEMICL STUDY OF ALKALI BURNS (KSHARA DAGDHA VRANA) IN ALBINO RATS

Sharma Sukrant, Bhardwaj Ashanka, Yadav Rajesh, Kour Sarabjeet

Abstract


Acharya Sushrutha mentioned alkali (kshara) as a substance which does debridement (ksharana) and cutting properties (kshanana)  and mentioned its properties like excision (chedana), incision (bhedana), scrapping (lekhana), purification (shodhana), healing (ropana) , cauterization(dahana)etc.

How a strong alkali, after injuring tissue, can itself induce healing needs investigation. With this objective, this experimental study on Albino rats was planned to observe and measure alkali induced tissue injury and its subsequent healing. Findings were compared with healing pattern of topical chemical tissue injury and healing using 2N-NaOH (2normal saline sodium hydroxide).

The parameters for assessing tissue injury and subsequent healing were total hematology, C-reactive protein, total protein, tissue hydroxyproline and histopathological study. The study revealed that the rate and extent of healing post-alkali (trial group) injury is much higher compared to chemical injury induced by 2N-NaOH (standard). Lesions treated by applying alkali leave wounds and these wounds need not be treated by other healing medicine. The alkali itself has property which leads to healing of its own wounds.


Keywords


Alkali, Wister Albino rats, Sodium hydroxide

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References


Acharya Sushruta, SushrutaSamhita; Dalhana, Nibandasangraha commentary; Edited by JadavjiTrikamji Acharya and Naarayan Ram Acharya; ChowkhambhaSurabhaarati Prakashan,Varanasi,1st edition; Reprint 2010; Sootrasthana 11/3,pg no.45.

Acharya Sushruta, SushrutaSamhita; Dalhana, Nibandasangraha commentary; Edited by JadavjiTrikamji Acharya and Naarayan Ram Acharya; ChowkhambhaSurabhaarati Prakashan,Varanasi,1st edition; Reprint 2010; Sootrasthana 11/6,pg no.46.

Annexure III,Kshara PH.

Annexure IV, Sodium hydroxide PH.

Acharya Sushruta, SushrutaSamhita; Dalhana, Nibandasangraha commentary; Edited by JadavjiTrikamji Acharya and Naarayan Ram Acharya; ChowkhambhaSurabhaarati Prakashan,Varanasi,1st edition; Reprint 2010; Sootrasthana 11/5,pn.45.

Comprehensive study on twak shareera and histological changes on application of kshara by Dr.Pralhad.D.Subbannavar in 2008 from RGUHS Bengaluru. (Unpublished).

Clinical study to evaluate local effects of pratisaaraniya kshara (apamarga) in dushta vrana by Dr.Vivek.N.Patil in 2011-12 from RGUHS Bengaluru. (Unpublished)


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