PATTERN OF DYSLIPIDAEMIA IN PATIENT WITH ANGIOGRAPHICALLY DOCUMENTED CORONARY ARTERY DISEASE

Md. Shahimur Parvez, Mohammad Arifur Rahman, Md. Moniruzzaman, Arin Islam Lita, Tamal Peter Ghosh, Abdul Wadud Chowdhury

Abstract


Background: Dyslipidaemia contributes to substantial increased risk of premature extensive and accelerated atherosclerosis leading to CAD, PVD and MI etc. Patients derive most benefit from treatment with lipid-lowering agents.

Objective: To evaluate the pattern of dyslipidaemia in patients with angiogram documented significant coronary artery disease (lesion ≥70 % stenosis).

Methods: This cross sectional analytical study was carried out in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka; University Cardiac Centre (UCC), Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka and Department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Shahbag, Dhaka (March 2011 to August 2011). A total number of 50 patients with angiogram documented coronary artery disease were included in this study. Stenosis ≥ 70% in any of the three major epicardial vessels was considered significant CAD. Total Cholesterol ≥200 mg/dl or LDLc ≥130 mg/dl or HDLc ≤40 mg/dl or Triglyceride ≥200 mg/dl were considered as dyslipidaemia. Considering the inclusion & exclusion criteria the study population were divided into two groups. Group-I: Patients with dyslipidaemia (n=43) and Group-II: Patients without dyslipidaemia (n=07).

Results: Almost one third (32.0%) of the patients were in 6th decade and male to female ratio was 5.3:1. Eighty percent of the patients had typical chest pain and 16.0% had shortness of breath. Regarding the traditional risk factors, dyslipidaemia (86.0%) was more common followed by hypertension (66.0%), diabetes (42.0%), smoking (40.0%) and family history of IHD (28.0%). Mean BMI of the Group-I was 25.46±3.69 and Group-II was 24.65 ± 4.21. Left main involvement was found in 4.0% and most of the patients (60.0%) had significant proximal lesion involvement that were 40.0% in LAD, 18.0% in LCX and 22.0% in RCA. The mean difference of fasting lipid profile was not statistically significant between smoker and non-smoker patients, hypertensive and normotensive, diabetic and non-diabetic patients with angiogram documented coronary artery disease (P>0.05).

Conclusion: Most of the patients with coronary artery disease had low HDL (84.0%) irrespective of taking lipid lowering medication.


Keywords


Dyslipidaemia, Coronary Angiography, Coronary Artery Disease

Full Text:

PDF

References


Reddy, K.S., Yusuf, S., et al., 1998. “Emerging epidemic of cardiovascular disease in developing countries”. Circulation; 97: pp. 596-601.

Nishtar, S. Et al., 2002. “Prevention of coronary heart disease in south Asia”. Lancet; 360: pp. 1015-18.

Yusuf, S., Reddy, S., Ounpuu, S., Anand, S., et al., 2002. “Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies”. Circulation; 104: pp. 2855-64.

Enas, E.A., Garg, A., Davidson, M.A., Nair, V.M., Huet, B.A., Yusuf, S., et al., 1996. “Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America”. Indian Heart Journal; 48: pp. 343-53.

Gahaffar, A., Reddy, K.S., Singhi, M.E., et al., 2004. “Burden of non-communicable disease in South Asia”. British Medical Journal; pp. 234:807.

Malik, A., Islam, M.N. Zafar, A., Khan, A.K., et al., 1976. “Clinical patterns of ischaemic heart disease and its association with some known risk factors”. Bangladesh Heart Journal; 2: pp.1-9.

Amanullah, M., et al., 1994. “Intravenous thrombolytics in acute myocardial infarction”. Bangladesh Heart Journal; 9: pp.1-4.

Gordon, T., Castelli, W.P., Hjortland, M., Kannel, W.B., Dawber, T.R., et al., 1977. “High Density Lipoprotein as a Protective Factor against Coronary Heart Disease. The Framingham Study”. American Journal of Medicine; 62: pp. 707-714.

Jacobs, D.R., Jr, Mebane, I.L., Bangdiwala, S.I., Criqui, M.H., Tyroler, H.A., et al., 1990. “High density lipoprotein as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study”. American Journal of Epidemiology; 131: pp. 32-47.

Tan, C., Emmanuel, S.C., Tan, B., Jacob, E., et al., 1999. “Prevalence of Diabetes and Ethnic Differences in Cardiovascular Risk Factors”. Diabetes Care; 22: pp. 241–247.


Refbacks

  • There are currently no refbacks.