THE EFFECT OF MUCİN-1, GLYCODELİN-A, LEUKEMİA INHİBİTORY FACTOR, INTERLEUKİN-15 AND GRANULOCYTE COLONY STİMULATİON FACTOR IN THE UNEXPLAINED RECURRENT PREGNANCY LOSS - A CASE CONTROL STUDY

Murat Polat, Nadi Keskin, Ghanim Khatib

Abstract


Purpose: To examine the effect on recurrent pregnancy loss of Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor blood serum levels and for those with the greatest effect to be able to contribute to alternative treatment approaches.

Materials and Methods: The study was conducted between November 2016 and December 2016 in the Obstetrics and Gynaecology Clinic of Evliya Celebi Training and Research Hospital, Dumlupinar University Medical Faculty. A total of 87 patients were included, comprising 42 patients who had experienced at least 2 consecutive pregnancy losses before the 12th week, and a control group of 45 patients with at least 1 live birth and no pregnancy loss. Examination was made of the blood plasma levels of Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor.

Results: In the patient and control groups the Mucin-1 plasma levels were determined as 0.88±0.45 ng/ml and 1.17±0.57 ng/ml (p=0.008) respectively, Glycodelin-a as 23.73 ng/ml and 25,92 ng/ml (p=0.006). Leukemia Inhibitory Factor as 64.59 pg/mL, and 72.14 pg/mL (p=0,011), Interleukin-15 as 38.57 ng/ml and 31.44 ng/ml (p=0.013), and Granulocyte Colony Stimulation Factor as 13.07 pg/mL and 14.11 pg/mL (p=0.056).

Conclusion: According to the results of this study, Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, and Interleukin-15 play an imprtant role in the pathology of RPL. Further studies conducted on these factors could be successful in the treatment of RPL.


Keywords


Recurrent pregnancy loss, Mucin-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15, Granulocyte Colony Stimulation Factor

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References


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