CORRELATION BETWEEN DURATION OF ILLNESS, FASTING AND RANDOM BLOOD GLUCOSE AND HBA1C LEVELS IN DIABETIC PATIENTS

Dr Vijay Singh Baghel, Dr Archana Saxena

Abstract


Introduction: Type2 diabetes mellitus is reaching epidemic proportions in the Indian subcontinent over the year. In this study we test for relationship between duration of illness, BMI and blood glucose levels with HBA1C value.

Material and Methods: 100 patients with Diabetes Mellitus were taken for this study. Their anthropometric and disease history was noted down and HbA1c and blood glucose levels were estimated biochemically and tests were applied to study correlation between various values.

Result: The duration of diabetes and BMI were not related to HbA1c levels, however FBG AND PPG were correlated significantly with HbA1c levels. Also BMI, duration of diabetes, FBG and PPG were found to be independent predictors of HbA1c levels in these patients.


Keywords


diseases, FASTING, RANDOM BLOOD GLUCOSE, HBA1C

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References


WHO Diabetes country profiles 2016. www. searo. who. int /india/ topics/diabetes_mellitus/en/

Mohan V, Anjana RM, Pradeep R, Unnikrishnan R, Kaur T, Das AK. The ICMR INDIA B Study-A Compendum of Type 2 Diabetes in India: Lesson learnt from the nation; Chapter 241:1104-1110.

Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK et al. Diabetes Epidemiology Study Group in India(DESI).High prevalence of diabetes and impaired glucose tolerance in India:National Urban Diabetes Survey. Diabetologia. 2001; 44:1094-1101.

Sadikot SM, Nigam A, Das S, Bajaj S, Zargar AH, Prasannakumar KM et al. Diabetes IndiaThe burden of Diabetes and Impaired glucose tolerance in India using the WHO 1999 criteria: Prevalence of Diabetes in India Study(PODIS).Diabetes Res Clin Pract.2004;66:301-307.

Singh RB, Pella D, Mechinova V, Kartikey K, Demeester F, Tomar RS et al. Five City Study Group.Prevalence of obesity,physical inactivity and undernutrition ,a triple burden of diseases during transition in a developing country. Acta Cardiol.2007 Apr;62(2):119-27.

Mohan V, Mathur P, Deepa R, Deepa M,Shukla DK, Menon GR, Ananad K, Desai NG, Joshi PP, Mahanta J, Thankappam KR, Shah B. Urban rural differences in India-the WHO-ICMR Indian NCD risk factor surveillance .Diabetes research and clinical practice.2008;80: 159-168.

World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO/IDF Consultation, Geneva, WHO.2006:39.

World Health Organization. Use of Glycated Hemoglobin in the diagnosis of Diabetes Mellitus: Abbreviated report of a WHO consultation.Geneva,WHO.2011:1-25.

D’Embden M. Glycated haemoglobin for the diagnosis of diabetes.Australian Prescriber.2014;37(3):98-100.

American Diabetes Association. Standards of medical care in diabetes-2012.Diabetes Care.2012;35 Suppl 1:511-63.

Nathan DM, Turgeon H, Regan S. Relationship between glycated haemoglobin levels and mean glucose levels over time. Diabetologia. 2007;50:2239-44.

Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem.1969;6:24-7.

Bisse E, Abraham EC. New less temperature sensitive microchromatographic method for the separation and quantitation of glycosylated haemoglobins using a non-cyanide buffer system.J.Chromatogr.1985;344:81-91.

Najeeb Q, Singh J, Pandey R, Mahajan R. A comparative study of fasting, postprandial blood glucose and glycosylated haemoglobin for diagnosing diabetes mellitus in staff members of MMIMSR, Mullana, Ambala. Medical Journal of Dr D.Y.Patil University. March-April 2015;8(2):158-164.

A r n e t z B.B, K a l l n e r A , T h e o r e l l T. T h e i n fl u e n c e o f a g i n g o n HbA1c.J.Gerontol.1982;37:648-650.

Kilpatrick ES, Dominiczak MH, Small M. The effects of aging on glycation and the interpretation of glycemic control in Type 2 diabetes.Q.J.Med.1996;89:307-312.

Kabadi UM. Glycosylation of proteins. Lack of influence on aging.Diabetes Care.1998;11:421-432.

Colditz GA, Willett WC, Stamofer MJ, Masson JE, Hennekens CH, Arky RA, Seizer FE. We i g h t a s a ris k f a c t o r f o r c l i n i c a l d i a b e t e s i n w o m e n . A m J Epidemniol.1990;132(3):501-513.

Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunction linking obesity to insulin resistance and Type 2 diabetes. Nat Rev Mol Cell Biol.2008;10(4):412-419.

Gupta S, Puppalwar PV, Chalak A. Correlation of fasting and post meal plasma glucose level to increased HbA1c levels in type 2 diabetes mellitus.int J Adv Med.2014;1(2):127-131.

Ghazanfari Z, Haghdoost AA, Alizadeh SM, Atapour J, Zolala F.A comparison of HbA1c and fasting blood sugar tests in general population.Int J Prev Med.2010;1(3):187-194.

Rohfling CL, Wiedmeyer HM, Little RR, Engkand JD, Tennill A, Glodstein DE. Defining the relationship between plasma glucose and HbA1c.Diabetes Care;25(2):275-273.

Tahara, Shima K. The response of GHb to stepwise plasma glucose change over time in diabetes patients. Diabetes Care.1993;16:1313-1314.


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