CLOZAPINE IN CHILDHOOD ONSET RESISTANT BIPOLAR DISORDER
Abstract
Recurrent episodes of bipolar disorder and consequent repeated hospitalizations can negatively impact the overall functioning and treatment compliance of bipolar patients. In all 7170 files were individually screened, patients included in the study had received clozapine for at least 6 weeks Nineteen patients were included in the final evaluation. Response to clozapine was assessed according to a four-point scale both in acute and maintenance phase. Those who continued their treatment maintained in remission and relapses were seen only on discontinuation of treatment. The results show clozapine is relatively well tolerated and efficacious in the childhood onset resistant bipolar disorder in terms of long periods of remission, fewer hospital visits, and hospitalization.
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