TO STUDY THEANTIOXIDANT EFFECT OF BRAHMI ON CATALASE AND GSH ACTIVITIY.

Gayatridevi Pushkar, Dr. Rohini Sivabalan

Abstract


The effect of Brahmi was studied on antioxidant activity since, impaired antioxidant activity is considered as key factor for neurodegenerative diseases. Brahmi is one of the reputed medicinal plant of the Ayurveda used as a nerve tonic since time immemorial. The effect of Brahmiwas assessed on catalase and reduced glutathione(GSH). There was significant increase in the activity of catalase and reduced glutathione (GSH) on treatment with Brahmi. The results suggest that Brahmi exhibits significant antioxidant effect and helps in reducing oxidative stress. The antioxidant activity, indirectly helps in cognition and this may be facilitating memory enhanching effect of Brahmi. Furthermore, the present study clearly indicates that the Brahmihas a significant potential as a natural antioxidant agent.  

 


Keywords


Brain;Antioxidants; Oxidative Stress; Antioxidant Catalase, Reduced glutathione, Brahmi.

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References


Anbarasi, K., Vani, G., Balakrishna, K., & Devi, C. S. (2006). Effect of bacosideA on brain antioxidant status in cigarette smoke exposed rats. Life sciences, 78(12), 1378-1384.

Bickford PC, Gould T, Briederick L, Chadman K, Pollock A, Young D, B Shukitt-Hale B, Joseph J (2000) Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res 866:211–217. doi:10.1177/1534582304270783

Chelikani P, Fita I, Loewen PC (2004) Diversity of structures and properties among catalases. Cell Mol Life Sci 61:192–208

Gassen M, Youdim MB. 1997. The potential role of iron chelators in the treatment of Parkinson’s disease and related neurological disorders. PharmacolToxicol 80: 159–166.

Gilchrist AL, Cowan N, Naveh-Benjamin M (2008) Working memory capacity for spoken sentences decreases with adult aging: recall of fewer but not smaller chunks in older adults. Memory 16:773–787. doi:10.1080/09658210802261124

Good PF, Werner P, Hsu A, Olanow CW, Perl DP. 1996. Evidence of neuronal oxidative damage in Alzheimer’s disease. Am J Pathol 149: 21–28.

Goth L (1991)A simple method for determination of serum catalase activity and revision of reference range. ClinicaChimicaActa 196: 143-151.

Halliwell B, Dietary polyphenols: good, bad, or indifferent for your health?,Cardiovascular Res 73(2), 341–347, 2007.

Halliwell B, Gutteridge JMC. 1999. Free radicals in biology and medicine. In Studies of Generalized Light Emission (Luminescence/fluorescence) , 3rd edn. University Press: Oxford, 387–388.

Halliwell, B., 1994. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344, 721– 724.

Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A (2001) Does oxidative damage to DNA increase with age? ProcNatlAcadSci U S A 98:10469–10474

James LE, Fogler KA, Tauber SK (2008) Recognition memory measures yield disproportionate effects of aging on learning face-name association. Psychol Aging 23:657–664. doi:10.1037/ a0013008

Kaustubh S. Chaudhari, Nishant R. Tiwari, Rakesh R. Tiwari, Rohan S. Sharma. Neurocognitive Effect of Nootropic Drug Brahmi( Bacopamonnieri ) in Alzheimer’s Disease. Ann Neurosci ,2017;24:111–122.

Navarro A, Gomez C, Sanchez-Pino M, Gonzalez H, Bandez MS, Boveris Ad, Boveris A (2005) Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Amer J PhysiolRegulIntegr Comp Physiol 289:R1392–R1399

NeetuSaini, Devinder Singh, RajatSandhir. Neuroprotective Effects of Bacopamonnieri in Experimental Model of Dementia.Neurochem Res (2012) 37:1928–1937.

Park DC, Lautenschlager G, Hedden T, Davidson NS, Smith AD, Smith PK (2002) Models of visuospatial and verbal memory across adult life span. Psychol Aging 17:299–320.

Russo A, Borrelli F. Bacopamonniera, a reputed nootropic plant: an overview. Phytomed 2005;12:305-17.


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