Dr. Abhishek Sharma, Dr. Nitin Bansal, Dr. Alok Kumar



T2DM and its link with inflammation has been researched in recent times. There is also evidence of interaction between glucose homeostasis and iron metabolism. Some studies show that serum ferritin, an acute phase reactant and indicator of body iron stores, is associated with glucose intolerance, T2DM as well as micro and macro vascular complications of diabetes. This study was carried out to evaluate the relationship between serum ferritin and glycemic status in diabetic patients.

Materials and Methods

100 individuals with type 2 diabetes (M: F=48:52, mean age 56.08 ± 9.52 years, BMI 24.85 ± 4.03 kg/m2), who visited a tertiary care hospital, and 100 age and gender matched controls were included. Exclusion criteria included the factors affecting serum ferritin levels like anaemia, chronic liver or kidney disease. Serum ferritin, HbA1c, FBS, PPBS were measured.


The mean Serum ferritin was significantly higher (p<0.01) (189.61 ± 156.99 ng/ml) in diabetic patients when compared to controls (88.74 ± 47.28 ng/ml). Serum ferritin had a positive correlation with HbA1c (r=0.85), FBS (r=0.91) and PPBS (r=0.77). Serum ferritin was significantly related to diabetes duration (p<0.05).


Diabetics have elevated ferritin levels which correlate with their glycemic status (HbA1c, FBS, PPBS). It may thus be used as a marker for glycemic control in diabetes.


Diabetes Mellitus, Ferritin, HbA1c, Inflammation, Iron

Full Text:



Alvin C. Powers. Diabetes mellitus. In: Dennis L. Kasper, Eugene Braunwald, Anthony S. Fauci, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, eds. Harrison’s Principles of Internal Medicine. 17th ed. New York, NY: McGraw-Hill; 2005: 2275.

International Diabetes Federation. IDF Diabetes Atlas, 8th edition.

Rena M. Pollack. Diabetes Care 2016;39(Suppl. 2): S244-S252

Donath E, Shoelson S. Type 2 diabetes as an inflammatory disease. Nature Reviews, Immunology 2011; 11:98-107.

Theil EC. Ferritin: Structure, gene regulation and cellular function in animals, plants, and microorganisms. Annu Rev Biochem 1987;56:289-315.

Smotra S, Tandon VR, Sharma S, Kudyar RP. Serum ferritin and type 2 diabetes mellitus. JK Science 2007; 164-6.

Fernandez-Real JM, Chico B, Moreno JM, Vendrell J, Bermejo AL, Ricart W. Circulating soluble transferrin receptors according to glucose tolerance status and insulin sensitivity. Diabetes Care 2007; 604-8.

Williams MJ, Poulton R, Williams S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis 2002; 165: 179-184.

Mainous AG 3rd, Wells BJ, Everett CJ, Gill JM, King DE. Association of ferritin and lipids with C-reactive protein. Am J Cardiol 2004; 93: 559-62.

American Diabetes Association. Diagnosis and classification of Diabetes mellitus. Diabetes Care 2018;41(Suppl. 1): S13–S27.

Thanna R, Nigosker S. Level of Serum ferritin and Glycated hemoglobin (HbA1C) in type 2 diabetes mellitus. International Journal of Medical and Health Research 2016; 2(2):49-51.

R Dr. Pramiladevi, Boke Dr. Umakanth, Kora Dr. Shreeram. Serum Ferritin Levels In Type II Diabetes Mellitus. Sch. J. App. Med. Sci., 2013; 1(5):472-475.

Age- and Sex-Specific Prevalence of Diabetes and Impaired Glucose Regulation in 11 Asian Cohorts by the DECODA Study Group. Diabetes Care Jun 2003; 26 (6) 1770-1780.

Maheshwari AV, Bhoi BK, Sadariya BR, Javia HN, Gusani JK, Sharma H. Correlation between serum ferritin and glycaemic control in patients of type 2 diabetes mellitus: a case control study. Int J Res Med Sci 2015;3:2327-30.

Petchiappan V, Sivakrishna N, Manickam S, Menon S. Glycaemic control and C - reactive protein levels in type 2 diabetes mellitus - how well they correlate?: a prospective study. Int J Res Med Sci 2019;7:1818-21.

Sharifi F and Sazandeh Sh. Serum ferritin in type2 diabetes mellitus and its relationship with HbA1c. Acta Med Iranica 2004; 42(2): 142-45.

Arora P. Correlation between Serum Ferritin and Glycated Hemoglobin Level in Patients of Type 2 Diabetes Mellitus. Int J Cur Res Rev. 2017;6(9)

Raj S. Rajan GV; Correlation between elevated serum ferritin and HbA1c in type 2 dibates mellitus. International Journal of Research in Medical Science, 2013;1(1):12-15.

Thilip Kumar G, Saravanan A, Ramachandran C and John Nitin Ashok. Mean blood glucose level and glycated haemoglobin level in patients of non-insulin dependent diabetes mellitus and its correlation with serum ferritin level. Int J Med Sci 2011; 4 (1& 2): 13-17.

Padmaja P, Shabana S and Shariq Mas. Serum ferritin and HbA1c in type 2 diabetes mellitus. Int J Clin and Biomed Res 2015; 1(3): 30-37.

Alam F, Fatima F, Orakzai S, Iqbal N, Fatima S. Elevated levels of Ferritin and hs-CRP in type 2 diabetes. Journal of the Pakistan Medical Association. 2014; 64(12):1389-91.

Koorts AM, Viljoen M. Acute Phase Proteins: Ferritin and Ferritin Isoforms. University of Pretoria, South Africa.2011;154-184.

Gallou G, Guilhem I, Poirier JY, Ruelland A, Legras B, Cloarec L. Increased serum ferritin in insulin-dependent diabetes mellitus: relation to glycemic control. Clin Chem 1994; 40: 947-8.

DeFronzo, R.A. The triumvirate: B-cell, muscle, liver. A collusion responsible for niddm. Diabetes 1988, 37,667–687.

Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, Luben Re et al. Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 2007; 50: 949-56.

Wlazlo, N.; van Greevenbroek, M.M.; Ferreira, I.; Jansen, E.H.; Feskens, E.J.; vanderKallen, C.J.;Schalkwijk, C.G.; Bravenboer, B.; Stehouwer, C.D. Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: The CODAM study. Acta Diabetol. 2015, 52, 337–348.

Opara, E.C. Role of oxidative stress in the etiology of type II diabetes and the effect of antioxidant supplementation on glycemic control. J. Investig. Med. 2004, 52, 19–23.

Fernández-Real JM, López-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002;51:2348–2354.

Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006;440:944–948.

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114:1752–1761.

Urakawa H, Katsuki A, Sumida Y, Gabazza EC, Murashima S, Morioka K, et al. Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab 2003;88:4673–4676.

Borah M., & Goswami R. (2016). Evaluation of serum ferritin in in type II diabetes mellitus: a hospital based observational study from Dibrugarh, Assam, India. International Journal of Research in Medical Sciences2016; 4(11), 4916-4921.

Gandhi S. J, Chaudhari A.S, Pratinidhi S. A, Sontakke A.N. Study of serum ferritin and HbA1c in Type 2 diabetes mellitus. Int J Clin Biochem Res. 2018;5(4):594- 598.

Jeevan K. Shetty, Mungli Prakash, Mohammad S. Ibrahim. Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications. Indian J Clin Biochem. 2008;23(1):67-70.

Moczulski DK, Grzeszczak W, Gawlik B; Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2diabetes and diabetic nephropathy. Diabetes Care, 2001; 24(7): 1187- 1191.


  • There are currently no refbacks.