Dr Maheshwar Reddy Kandi, Dr Sindhuja Arikanti, Dr A Srikanth Reddy


AIM: To evaluate the clinical effects & adverse events when fentanyl & dexmedetomidine are used as additives to 0.75% Ropivacaine for epidural anesthesia.  

METHODS: Institutional ethical committee clearance was obtained.A total of 80 patients of both sex,aged 18-60 years,ASA grade I,II posted for elective lower limb surgeries were divided into two groups(n=40) by open label randomization method.Group RF received 1μg/kg Fentanyl & group RD received 1μg/kg Dexmedetomidine along with 15 ml Ropivacaine 0.75% in both groups. Onset of complete motor & sensory blockade,duration of analgesia, two segmental dermatomal regression & adverse effects were recorded. Data was analysed using Fisher’s exact test & Chi-square test. Value of P<0.05 is considered significant and P<0.001 as highly significant.

RESULTS: The demographic profile was comparable in both the groups. Onset of sensory analgesia at T10 (10.04±0.86 vs 13.76±1.42) & onset of complete motor blockade (16.5±1.24 vs 20.4±1.32) was significantly earlier in RD group as compared to RF group. Duration of motor and sensory block was significantly longer in group RD (194.2. ± 20.73 and 150.42 ± 5.18 min) as compared to group RF (162.32 ± 22.38 and 122.4 ± 3.46 min).Incidence of  bradycardia,hypotension & dry mouth was significantly higher in the RD group whereas incidence of nausea & vomiting was significantly higher in RF group with P < 0.05.

CONCLUSION : Epidural anesthesia with dexmedetomidine as an additive to 0.75% ropivacaine is more effective with respect to earlier onset & prolonged duration of sensory & motor blockade when compared to fentanyl.


Dexmedetomidine, epidural anesthesia, fentanyl, ropivacaine.

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