A STUDY ON CORRELATION BETWEEN ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR, HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR-2 STATUS AND OTHER PROGNOSTIC FACTORS IN CARCINOMA BREAST

Abstract

The study aimed to evaluate the correlation of prognostic factors such as age, BMI, ER, PR, HER2 receptor status in-patients with carcinoma of breast to study the correlation between hormonal receptors status and other prognostic factors with lymphovascular invasion in carcinoma breast. A total of 160 patients with carcinoma breast presented to Madras Medical College, Rajiv Gandhi Government General Hospital from February 2019 to November 2019 were chosen & recorded along with Data were processed using SPSS software. It was found that an increase in the incidence of breast carcinoma is high in the peri-menopausal age group (40–50) years of age. From this study, we conclude that Positive receptor status (ER, PR and, HER2NEU) is found in the majority of the women with normal BMI and negative receptor status is associated with obese patients. Positive receptor status (ER, PR) is associated with decreased lymphovascular invasion and negative receptor status is associated with increased lymphovascular invasion. Normal BMI is associated with decreased lymphovascular invasion in both pre and post-menopausal women in contrast to obese patients. It can also be concluded that lymph node with lymphovascular invasion HER 2 NEU with lymphovascular invasion is Statistically insignificant.