COMPARISON OF INTRAVENOUS PARACETAMOL AND INTRAVENOUS KETOROLAC AS PREEMPTIVE ANALGESIA IN LAPAROSCOPIC SURGERIES

Abstract

INTRODUCTION: Preemptive analgesia is one of the upcoming strategies of pain management. Its an analgesic intervention before the surgical noxious stimulus arises. The aim of this study is to compare between the administration
of I.V. Paracetamol and I.V. Ketorolac as preemptive analgesia in regards of hemodynamic, pain control, duration of analgesia, cumulative doses of intraoperative opioids and their related side-effects and to compareefficacy between these drugs for postoperative analgesia and their cumulative doses.

MATERIALS AND METHODS: Patients will be randomized into two groups, Group P and Group K of 24 patients each belonging to both sexes of American Society of Anesthesiologists physical status I and II, aged 18-58 years with body
weight of 50-60 kg scheduled for elective laparoscopic procedures with duration less than 3hours under general anesthesia. Group P will be receiving I.V. Paracetamol 1gm and Group K will be receiving I.V. Ketorolac 30mg . VAS score
was assessed immedietly from the post operative period till 12 hours.

RESULTS: In our study we found that postoperative VAS score was statistically significant, with a p value<0.0among the patients who received I.V.Ketorolac infusion in the immediate post operative period till 12 hours. The use of rescue
analgesia was more among the Paracetamol group that was 6 patients when compared to 2 patients among the Ketorolac group.

CONCLUSION: Preemptive use of Ketorolac infusion provides better andprolonged post operative analgesia with low pain scores and lesser requirement of rescue analgesia, compared to Paracetamol infusion .