A STUDY OF CORRELATION BETWEEN SERUM VITAMIN D LEVELS WITH LEVEL OF CONTROL OF CHILDHOOD ASTHMA AT PEDIATRICS DEPARTMENT OF NMCH, PATNA, BIHAR
Abstract
Objective: To study the association between serum vitamin D levels and levels of asthma control in children aged 5-15 years. Methods: Children with physician-diagnosed asthma who were under follow-up for at least 6 months were enrolled. Participants were categorized into three asthma control groups as per standard guidelines, and their serum 25-hydroxy vitamin D levels and pulmonary function tests were compared. Results: Out of 105 children with asthma enrolled in the study, 50 (47.6%) were controlled, 32 (30.5%) were partly controlled and 23 (21.9%) were uncontrolled. Median (IQR) serum vitamin D levels in these three groups were 9.0 (6.75, 15) ng/mL, 10 (6.25, 14.75) ng/mL and 8 (5, 10) ng/mL (P=0.24), respectively. Conclusion: We did not observe any association of serum 25-hydroxy vitamin D levels with the level of control of childhood asthma.
Keywords
Full Text:
PDFReferences
Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105:91-9.
Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academic Press, 2011. Available from: http://www.ncbi.nlm.nih.gov/books/NBK56070/. Accessed November 27, 2014.
Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guideline. J ClinEndocrinolMetab. 2012;97:1146-52.
Awasthi S, Vikram K. Serum 25 hydroxy vitamin D insufficiency associated with bronchial asthma in Lucknow, India. Indian J Pediatr. 2014;81:644-9.
Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J RespirCrit Care Med. 2011;184:1342-9.
Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DYM. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy ClinImmunol. 2010;125:995-1000.
Krobtrakulchai W, Praikanahok J, Visitsunthorn N, Vichyanond P, Manonukul K, Pratumvinit B, et al. The effect of vitamin D status on pediatric asthma at a university hospital, Thailand. Allergy Asthma Immunol Res. 2013;5:289-94.
Lewis E, Fernandez C, Nella A, Hopp R, Gallagher JC, Casale TB. Relationship of 25-hydroxyvitamin D and asthma control in children. Ann Allergy Asthma Immunol. 2012;108:281-2.
Bar Yoseph R, Livnat G, Schnapp Z, Hakim F, Dabbah H, Goldbart A, et al. The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double-blind placebo-controlled trial. PediatrPulmonol. 2015;50: 747-53.
WHO. Growth Reference Data for 5-19 years. Available from: http://www.who.int/growthref/en/. Accessed November 27, 2014.
Refbacks
- There are currently no refbacks.