Dr. Arghya Maitra, Dr. Priyadarshi Kundu


AIMS & OBJECTIVE: To evaluate and compare the efficacy of loading dose (reduced dose) magnesium sulphate with
standard Pritchard's regime in severe Preeclampsia & Eclampsia patients for analysis of maternal and fetal outcome with
MgSO4 toxicity and side effects in both the regimes irrespective of state of pregnancy and period of gestation.
MATERIALS & METHODS: A prospective observational study conducted in the Department of Obstetrics and
Gynaecology, Calcutta National Medical College, Kolkata, during the period MARCH 2018 to FEBRUARY 2019. A total
number of 100 patients were taken for the study, out of which 50 were severe preeclamptic\ eclamptic patients cases and
equal number of controls ( In Antepartum eciampsia patients to whom standard Pritchard's regime given. )
RESULTS: In the present study maximum number of patients belong to teenage group. Incidence of Eclampsia is high in
this age group. Loading dose of Magsulf is as effective as standard regime in controlling seizures in eclampsia and
preventing the seizures in severe preeclampsia. The recurrent seizures rate were almost the same in both the group.
CONCLUSION: Single loading dose (reduced dose) magnesium sulphate is efficacious in preventing recurrence of
convulsions and Perinatal & Maternal outcome is better and toxicity of MgSO4 is less in our study.


Preeclampsia, Eclampsia, Magnesium sulphate.

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