Prasanta Kumar Maiti, Rehana Parveen, Paramita Ghosh


Silver nanoparticles (AgNPs) possess potent pan-microbicidal properties with non-specific synergisms for different
antimicrobial agents, yet none found suitable for systemic use for potential risk of host cell damage. AgNPs prepared
from silver nitrate using dextrose as reducing and human serum as mixture of stabilizing agents, also show all
antimicrobial properties. There is least possibility of internalization by receptor-ligand attachment in human cells and
liberation of any toxic components after de-capping for bio-mimicking outer coat. For their antimicrobial actions against
different multi-drug resistant pathogens at any point of cell cycle and wide range nonspecific synergism with different
antibiotics, can be used at safe low dosage with or without synergistic antibiotics. In-vitro study on human liver cell-line
(WRL-68) and in-vivo study in mice model indicated wide margin of safety. Thus, major life-threatening infections caused
by super-bugs can be managed in future by such safe systemic useable Nano-antimicrobials.


Silver nanoparticles, Anti-microbial agent, Systemic usable drug, Cytotoxicity.

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