THE ADVANTAGES OF USING MESENCHYMAL STEM CELLS IN THE TREATMENT OF MASSIVE BURNS – CASE REPORT

Ana- Maria Oproiu, Anamaria Grigore

Abstract


Due to insufficient oxygenation of tissues, cellular and vascular destruction, burns show a different healing process from
other wounds. Even if it affects only one organ, namely the skin, burns can generate a systematic response in which
1 multiple organs are affected, and the risk of infections and mortality are higher . Therefore, burns require the
involvement of several specialities, special care, long hospitalizations and multiple surgical interventions, depending on
the the way of production, the surface and the depth. Even if the medicine has evolved, and the mortality of burns has
also improved, the healing process is often unsatisfactory with negative consequences on the functional and physical
aspects, reducing the quality of the patient`s life. This paper aims to present a different approach in the management of a
II-III-degree burns, of approximately 20% body surface, at the level of the posterior thorax and the left upper extremity.
This approach consists of using mesenchymal stem cells. The procedure involves the collection of skin samples with a
diameter of 5 mm each one, mix them with saline solution, introduce them in a special device, disaggregate them and
inject the resulting suspension solution abundant in mesenchymal stem cells into the dermis. The advantages are that it
can skip over the excisional debridement stage and the skin graft donor areas are significantly decreased from the
standard approach, and other possible subsequent. surgical interventions.


Keywords


Burns, Wounds, Skin , Healing Process, Mesenchymal Stem Cells

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References


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