A SINGLE CENTRE PILOT STUDY COMPARING THE EFFECT OF ENDOMETRIAL SCRATCHING VS HYSTEROSCOPY ON PREGNANCY OUTCOME OF WOMEN UNDERGOING IVF

Dr Rita Bakshi, Dr Khushboo Sharma, Dr Deepali Dhingara

Abstract


Objective: To compare the effect of endometrial scratching vs hysteroscopy on pregnancy outcome of women undergoing IVF with previously
failed ART cycles.
Methods: 40 patients were recruited from July 2019 to August 2019. They were alternately subjected to hysteroscopy and endometrial scratching
prior to controlled ovarian stimulation. The endpoint was clinical pregnancy as assessed by cardiac activity.
Result: Clinical pregnancy rate was 40% in hysteroscopy group and 35% in scratching group. There was no statistically significant difference.
Conclusion: There is no difference in outcome with both procedures and either of them can be used before IVF procedure to improve the
pregnancy rate


Full Text:

PDF

References


Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med 2009; 360: 236-43.

Luke B, Brown MB, Wantman E, et al. Cumulative birth rates with linked assisted reproductive technology cycles. N Engl J Med 2012; 366: 2483-91.

Toftager M, Bogstad J, Løssl K, et al. Cumulative live birth rates after one ART cycle including all subsequent frozenthaw cycles in 1050 women: secondary outcome of an RCT comparing GnRHantagonist and GnRH-agonist protocols. Hum Reprod 2017; 32: 556-67.

Mak JSM, Chung CHS, Chung JPW, Kong GWS, Saravelos SH, Cheung LP, et al. The effect of endometrial scratch on natural-cycle cryopreserved embryo transfer outcomes: a randomized controlled study. Reprod Biomed Online 2017;35:28–36.

N E van Hoogenhuijze, J C Kasius, F J M Broekmans, J Bosteels, H L Torrance. Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis. Human Reproduction Open, Volume 2019, Issue 1, 2019, pp 1–18

Di Spiezio Sardo A, Di Carlo C, Minozzi S, Spinelli M, Pistotti V4, Alviggi C2, De Placido G2, Nappi C5, Bifulco G2 Efficacy of hysteroscopy in improving reproductive outcomes of infertile couples: a systematic review and meta-analysis. Hum Reprod Update. 2016 Jun;22(4):479-96. doi: 10.1093/humupd/dmw008. Epub 2016 Mar 23.

Singh N, Toshyan V, Kumar S, Vanamail P, Madhu M Does endometrial injury enhances implantation in recurrent in-vitro fertilization failures? A prospective randomized control study from tertiary care center J Hum Reprod Sci. 2015 Oct-Dec;8(4):218-23. doi: 10.4103/0974-1208.170401.

Tk A, Singhal H, S Premkumar P, Acharya M, S Kamath M, George K. Local endometrial injury in women with failed IVF undergoing a repeat cycle: A randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2017 Jul;214:109-114. doi: 10.1016/j.ejogrb.2017.05.005. Epub 2017 May 4.

Maged AM, Rashwan H, AbdelAziz S, Ramadan W, Mostafa WAI, Metwally AA, Katta M Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle. Int J Gynaecol Obstet. 2018 Feb;140(2):211-216. doi: 10.1002/ijgo.12355. Epub 2017 Nov 18.

Lensen S, Osavlyuk D, Armstrong S, Stadelmann C, Hennes A, Napier E, Wilkinson J, Sadler L, Gupta D, Strandell A, Bergh C, Vigneswaran K, Teh WT, Hamoda H, Webber L, Wakeman SA, Searle L, Bhide P, McDowell S, Peeraer K, Khalaf Y, Farquhar C. A Randomized Trial of Endometrial Scratching before In Vitro Fertilization. N Engl J Med. 2019 Jan 24;380(4):325-334. doi: 10.1056/NEJMoa1808737.

Rama Raju GA, Shashi Kumari G, Krishna KM, Prakash GJ, Madan K. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Arch Gynecol Obstet. 2006 Jun;274(3):160-4. Epub 2006 May 10.

El-Toukhy T, Campo R, Khalaf Y, Tabanelli C, Gianaroli L, Gordts SS, Gordts S, Mestdagh G, Mardesic T, Voboril J, Marchino GL, Benedetto C, Al-Shawaf T, Sabatini L, Seed PT, Gergolet M1, Grimbizis G1, Harb H1, Coomarasamy A. Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial. Lancet. 2016 Jun 25;387 (10038):2614-2621. doi: 10.1016/S0140-6736(16)00258-0. Epub 2016 Apr 27.

Hossam Eldin Shawki *, Mahmoud Elmorsy, Mostafa K. Eissa. Routine office hysteroscopy prior to ICSI and its impact on assisted reproduction program outcome: A randomized controlled trial. Middle East Fertility Society Journal (2012) 17, 14–21


Refbacks

  • There are currently no refbacks.