Aruna Selvambika K, Kishan A Shetty


Introduction: General anaesthesia with endotracheal intubation and IPPV/ spontaneous ventilation is commonly practised by anaesthesiologist
for many surgical procedures. Tracheal intubation is one of the most painful procedures. So adequate blunting of the intubation response is required
to avoid hemodynamic instability following intubation. Our aim was to compare the response to intubation following intravenous and nebulisation
of lignocaine.
Methodology: A prospective, observational, double blinded, randomized controlled trial using a sample size of 60 patients of either sex who comes
under ASA I & II admitted for elective surgeries under general anaesthesia was conducted in Father Muller medical college, Mangalore after
institutional ethical clearance. Patients were divided into two groups. Group A received intravenous 2% Lignocaine 1.5 mg/kg and the group B
received 4% Lignocaine nebulisation. Data were recorded as means, standard deviation and percentages. The categorical co varieties (sex, ASA
grade) were analysed using the Chi-Square test and Fishers exact test. The intergroup comparison of the parametric data (age, weight, height,
hemodynamic response) were done using student t- test.
Result: The maximum increase in Heart rate was 109.73±15.34 bpm in Group A and 95.00±32.334 bpm in Group B at 1 minute after endotracheal
intubation. The maximum increase in systolic BP was 166.7±20.5 mm of Hg in Group A and 144.67±17.43 mm of Hg in Group B at 1 minute after
endotracheal intubation. The maximum increase in diastolic BP was 105.13±11.78 mm of Hg in Group A and 97.27±12.2 mm of Hg in Group B at 1
minute after endotracheal intubation. The maximum increase in mean arterial BP was 125.71±8.19 mm of Hg in Group A and 114.67±12.83 mm of
Hg in Group B at 1 minute after endotracheal intubation.
Conclusion: Our study concludes that inhaled 4% Lignocaine can control the hemodynamic changes of intubation more effectively than IV 2%


Intubation response, Intravenous Lignocaine, Inhaled Lignocaine.

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